Opacity (Opa) protein variation in Neisseria gonorrhoeae is implicated in the pathogenesis of gonorrhea, possibly by mediating adherence and entry of the bacteria into human tissues. One particular Opa protein mediates adherence to epithelial cells through cell surface proteoglycans. Recently, two other eukaryotic cell receptors for Opa proteins have been reported. These receptors are members o...

BACKGROUND The purpose of our study was to: (1) investigate the macular pigment optical density (MPOD) and ocular pulse amplitude (OPA) in subjects with different axial lengths (AL) and refractive errors (RE); (2) determine if there is a correlation between MPOD and OPA; and (3) evaluate whether MPOD and OPA depend on intraocular pressure (IOP). MATERIAL AND METHODS This study included 140 ey...

Opa proteins are major surface-expressed proteins located in the Neisseria meningitidis outer membrane, and are potential meningococcal vaccine candidates. Although Opa proteins elicit high levels of bactericidal antibodies following immunisation in mice, progress towards human clinical trials has been delayed due to previous findings that Opa inhibits T cell proliferation in some in vitro assa...

Octadecylphosphonic acid (OPA) forms monolayers on amorphous smooth titania surfaces. The OPA was deposited by immersion in tetrahydrofuran solutions. The process takes place rapidly at 2× 10−4 M OPA, evidence of which is an advancing water contact angle of approx. 100◦ after 10 s of immersion. The advancing water contact angle plateaus at 110± 2◦ after several hours. At lower concentrations (2...

The neisserial opacity (Opa) proteins are a family of antigenically distinct outer membrane proteins that undergo phase-variable expression. Opa(+) variants of Neisseria gonorrhoeae strain FA1090 are selected in a cyclical pattern from the lower genital tract of estradiol-treated mice. Here we show that cyclical recovery of Opa(+) gonococci does not occur in ovariectomized mice; therefore, the ...

PURPOSE The aim of this study was to compare the ocular pulse amplitude (OPA) in patients with different types of glaucoma, and also to evaluate the usefulness of OPA for the elucidation of normal-tension glaucoma (NTG). OPA is thought to reflect choroidal circulation. SUBJECTS Sixty-six patients with normal-tension glaucoma (NTG), 52 patients with primary open angle glaucoma (POAG), 42 with ...

Condensed octadecylphosphonic acid (OPA) dimers, i.e., two OPA molecules combined with the loss of a water molecule, were detected by time-of-flight secondary ion mass spectrometry (TOF-SIMS) on OPA self-assembled monolayers (SAMs) that are only weakly bonded on the native oxide layer of a silicon wafer. In contrast, these condensed dimers were absent on OPA SAMs formed on the oxide layer of an...

OBJECTIVE Physical inactivity is a major health risk for working adults, yet the interplay between physical activity levels in work and non-work settings is not well understood. The association between occupational physical activity (OPA) and non-occupational physical activity (non-OPA), and associations by sex, were examined in a group of 233 working adults in the Minneapolis, MN metro area be...

We describe a simple experimental approach for delivering self-assembled monolayers (SAMs) of octadecylphosphonic acid (OPA) on many oxide surfaces using a nonpolar medium with a dielectric constant around 4 (e.g., trichloroethylene). This approach readily results in the formation of full-coverage OPA SAMs on a wide variety of oxide surfaces including cleaved mica, Si wafer, quartz, and aluminu...