Elder women suffer from low or loss of fertility because of decreasing oocyte quality as maternal aging. As energy resource, mitochondria play pivotal roles in oocyte development, determining oocyte quality. With advanced maternal age, increased dysfunctions emerge in oocyte mitochondria, which decrease oocyte quality and its developmental potential. Mitochondria supplement as a possible strate...

Abstract With the development of society, there has been a significant delay in female fertility and an increasing desire for childbearing among females advanced maternal age recent decades. Nevertheless, women over 35 years old have more risk infertility miscarriage compared to young women, due decreased oocyte quality. These changes are mainly caused by meiotic defects, especially aneuploidy....

Reproductive aging has become an important social and medical development. the trend to delay childbearing in modern societies to a much less fecund age often confronts women with difficulties to conceive. the aging of the ovary resulting in a decline in the total number of oocytes and in their quality cannot be undone. However, it often engenders unrealistic expectations of what modern fertili...

Reproductive aging and assisted reproduction are becoming progressively more relevant in human medicine. Research with human subjects is limited in many aspects, and consequently animal models may have considerable utility. Such models have provided insight into follicular function, oocyte maturation, and reproductive aging. However, models are often selected based on factors other than physiol...

BACKGROUND Ovarian aging patterns differ between races, and appear to affect fertility treatment outcomes. What causes these differences is, however, unknown. Variations in ovarian aging patterns have recently been associated with specific ovarian genotypes and sub-genotypes of the FMR1 gene. We, therefore, attempted to determine differences in how functional ovarian reserve (FOR) changes with ...

Histone modifications are associated with many fundamental biological processes in cells. An emerging notion from recent studies is that meiosis stage-dependent histone modifications are crucial for the oocyte development in mammals. In this paper, we review the changes and regulation as well as functions of histone modifications during meiotic maturation of mammalian oocyte, with particular em...

Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5- to 6-week-old mice with those collected from 42- to 45-week-old mice using the NIA 22K 60-mer oligo microarray. Among approximately 11,000 genes whose transcript...

Abstract Background Several studies have shown that coenzyme Q10 (CoQ10) can rescue ovarian aging and surface epithelium (OSE)-derived stem cells (OSCs) are useful for treating infertility due to aging. However, few examined the effect of CoQ10 on OSCs. This study was aimed investigate whether activates OSCs recovers function in a 4-vinylcyclohexene diepoxide (VCD)-induced mouse model failure. ...

We recently associated ovarian FMR1genotypes and sub-genotypes with distinct ovarian aging patterns. How they impact older females is, however, unknown. We, therefore, investigated 217 consecutive first in vitro fertilization (IVF) cycles in women >40 assessing oocyte yields, stratified for better (anti-Müllerian hormone, AMH >1.05 ng/mL) or poorer (AMH ≤ 1.05 ng/mL) functional reserve (FOR)). ...