results of all the ms patients, 78 (95.1%) and 21 (25.6%) were positive for anti-vzv and vzv dna, respectively. statistical analysis of the pcr results showed a significant correlation between the abundance of vzv and ms disease (p < 0.001). however, there was no significant correlation between the abundance of anti-vzv antibodies and ms disease by the elisa method. conclusions these results su...

background: intravenous immunoglobulin (ivig) is an established treatment of immune mediated demyelinating neuropathy including guillain-barré syndrome and chronic inflammatory demyelinating polyneuropathy. recent trials suggest its efficacy in treating relapsing- remitting multiple sclerosis. ivig exerts a number of effects, which may be beneficial in treating multiple sclerosis (ms): reductio...

Background: Multiple sclerosis and other demyelinating processes are sometimes difficult to differentiate from the neurological involvement in autoimmune diseases. Distinguishing multiple sclerosis from other lesions due to autoimmune diseases is crucial to avoid unsuitable or delayed treatments. Methods: Charts of 6 patients diagnosed with mimicking multiple sclerosis between 1996 and 2014 we...

The COVID-19 pandemic calls for correct and evidence-based decisions regarding management treatment of patients with multiple sclerosis. Information on researches, clinical cases, recommendations such during the should be classified. We report features in sclerosis, risk factors infection development severe disease. also describe strategies sclerosis: from relapse to selection disease-modifying...

tuberous sclerosis complex (tsc) is an autosomal-dominant hereditary disorder. this syndrome is characterized by tumor-like malformations in several organs, as well as the heart. this report summarizes a case of tsc in a premature infant, born at 34 weeks' gestation with ascites. after birth, multiple cardiac mass, subependymal cysts and hypopigmented macules were detected. to our knowledge, th...

The ages of onset in multiple sclerosis cases span more than 7 decades. Data are presented for affected relative pairs from a Canadian population base of 30,000 multiple sclerosis index cases (1993-2008). The effects of genetic sharing, parent of origin, intergenerational versus collinear differences, and gender on the ages of onset were evaluated in the following concordant pairs: monozygotic ...

The vast majority of patients are mildly affected, but in the worst cases MS can render a person unable to write, speak, or walk. A physician can diagnose MS in some patients soon after the onset of the illness. In others, however, physicians may not be able to readily identify the cause of the symptoms, leading to years of uncertainty and multiple diagnoses punctuated by baffling symptoms that...

conclusions the current study adds evidence to the association of tnf-α gene polymorphism and ms in this southern south iranian population which is consistent with the genetic analysis of ms in europeans (games) project reports and these two alleles reported in this study may be one of the genetic risk factor for ms. furthermore, this data can be used to build the iranian gene bank for future s...