The mitochondrial inner membrane (IM) serves as the site for ATP production by hosting the oxidative phosphorylation complex machinery most notably on the crista membranes. Disruption of the crista structure has been implicated in a variety of cardiovascular and neurodegenerative diseases. Here, we characterize ChChd3, a previously identified PKA substrate of unknown function (Schauble, S., Kin...

The crista terminalis is a normal anatomical structure within the right atrium that is not normally visualised in the standard views obtained while performing a transthoracic echocardiogram. In this case report, transthoracic echocardiography suggested the presence of a right atrial mass in a patient with end stage renal disease. However, subsequent transesophageal echocardiography revealed tha...

The study evaluated the in vitro iron chelating, lipid peroxidation inhibitory and DNA protective activities of hydroalcoholic (60% ethanolic) extracts of various plant parts of Terminalia chebula, Caesalpinia crista, Cajanus cajan, Terminalia belerica, Emblica officinalis, and Tinospora cordifolia. The iron chelating property of the plants is in accordance with the order of their IC50 values f...

In the rabbit, the sinus node is surrounded by a group of cells which we have termed perinodal fibers. Since sinus node impulses preferentially proceed to the crista terminalis and then spread to the rest of the atrium, we selected the zone of perinodal fibers lying between the sinus node and the crista terminalis for study. Values of transmembrane potentials and the maximum rate of rise (Vmax)...

The sensory patches of the vertebrate inner ear, which contain hair cells and supporting cells, are essential for hearing and balance functions. How the stereotypically organized sensory patches are formed remains to be determined. In this study,we isolated a zebrafish mutant in which the jag1b gene is disrupted by an EGFP insertion. Loss of Jag1b causes cell death in the developing posterior c...

Intracellular injections of the fluorescent dye Lucifer yellow into the various cell types within the anterior transverse crista segment of the statocyst of squid revealed that the primary sensory hair cells and both large and small first-order afferent neurons have relatively simple morphologies, each cell having a single, unbranched axon that passes directly into the small crista nerve that i...

The sensory patches of the vertebrate inner ear, which contain hair cells and supporting cells, are essential for hearing and balance functions. How the stereotypically organized sensory patches are formed remains to be determined. In this study,we isolated a zebrafish mutant in which the jag1b gene is disrupted by an EGFP insertion. Loss of Jag1b causes cell death in the developing posterior c...

In the rabbit, the sinus node is surrounded by a group of cells which we have termed perinodal fibers. Since sinus node impulses preferentially proceed to the crista terminalis and then spread to the rest of the atrium, we selected the zone of perinodal fibers lying between the sinus node and the crista terminalis for study. Values of transmembrane potentials and the maximum rate of rise (Vmax)...

The use of electron tomography has allowed the three-dimensional membrane topography of the mitochondrion to be better understood. The most striking feature of this topology is the crista junction, a structure that may serve to divide functionally the inner membrane and intermembrane spaces. In situ these junctions seem to have a preferred size and shape independent of the source of the mitocho...