1. Blood pressure was monitored continuously in conscious rats with chronic Goldblatt two-kidney, one-clip hypertension. 2. Hypertension was rapidly reversed by removal of the constricting clip and the reversal was complete by 12 h, although structural vascular changes persisted for much longer. 3. Blood pressure in this model of hypertension was not affected by a 15 h infusion of either indome...

The objective of this study was to determine the chronology of changes in blood pressure in renalhypertension induced by solid plexiglass clips in rats. Saw blades with the thickness of 0.21-0.22 mm wereused to make clips sized 4 × 2 × 2 mm from a piece of 2-mm thick plexiglass. Rats were subjected to shamoperation or left renal arterial clipping, and 1, 2, 3 and 4 weeks later blood pressure, a...

1. During the development and maintenance of one-kidney, one-clip hypertension in rats, there were no significant differences in blood volume or interstitial fluid pressure compared with one-kidney control rats. 2. Rats with one-kidney, one-clip hypertension of 25 days' duration were either unclipped, sham-operated or nephrectomized. Over 24 h the changes in arterial pressure, blood volume and ...

To investigate the possible role of body fluid volume or the renin-angiotensin system in the maintenance of high blood pressure in chronic one-kidney, one clip (1K1C) hypertension, we studied whether blood pressure remained high after removal of the clip while the body fluid volume was kept constant or when angiotensin II (Ang II) was infused in conscious 1K1C rats. Blood pressure fell 58 +/- 1...

1. Phenylethanolamine N-methyltransferase (PNMT) converts noradrenaline into adrenaline and brain PNMT is elevated in spontaneously hypertensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. In view of the evidence for the involvement of central adrenergic neurons in renal hypertension, we measured the blood pressure response in one-clip, one-kidney Goldblatt hypertensive and D...

The effects of potassium loading on blood pressure (BP) and the renin-angiotensin-aldosterone system were investigated in two-kidney, one clip Goldblatt hypertensive rats. Two series of experiments were performed: one was begun just after renal artery constriction, and the other, after hypertension had developed. Potassium loading significantly attenuated the development of hypertension, and wa...