Antibody in the sera of 15B X 7(2) chickens was measured for reactivity to determinants of the envelope glycoprotein of endogenous and exogenous avian tumor viruses. The pattern of reactivity of animals infected with exogenous sarcoma virus served to operationally define a class of determinants present on the envelope glycoprotein of exogenous viruses and absent from that of the endogenous viru...

Rifampicin, a semisynthetic antibiotic, is known to inhibit the bacterial DNA-dependent RNA polymerase (1), the growth of some animal viruses (2), and the focus formation induced by oncogenic viruses (3, 4). While certain derivatives of rifampicin can inhibit the RNA-dependent DNA polymerase activity of oncogenic viruses, and a similar activity found in normal and virus-transformed cells (5-7),...

cells were not neoplastic. The anisonucleolinar cells were derived from malignant tumors or were converted either by oncogenic viruses or “spontaneously― in culture. The present report is an extension of these observations to other types of cells and considers the relationship of the morphology of the nucleolini to various conditions of culture, karyotype, and the biological properties of c...

In the preceding paper' it was shown that antibody-like factors, endowed with a suppressing power for viruses inducing tumors in the fowl, are present in the blood serum of a great majority of adult chickens, while they are generally lacking in the sera of chicks and pullets. The next logical step was to compare the reaction induced by such viruses injected into the blood stream of chicks with ...

the Seventeenth Annual Symposium on Fundamental Cancer Research, 1963. Edited by R. W. Cumley. (Pp. 669; figs. 288. 128s.) London: Bailliere, Tindall & Cox, 1964. V IRUSES, Nucleic Acids and Cancer is a collection of papers presented at the 17th Annual Symposium on Fundamental Cancer Research in 1963. It is a book for research workers, by research workers and is primarily concerned with oncogen...