We investigated the synergism of colistin and imipenem against a multidrug-resistant K. pneumoniae isolate which was recovered from a severe hip infection. PCR and DNA sequencing were used to characterize the outer membrane porin genes and the resistance genes mediating the common β-lactamases and carbapenemases. Synergism was evaluated by time-kill studies. The bla SHV-31, bla CMY-2, and bla D...

Clinical isolates of Klebsiella pneumoniae resistant to carbapenems and essentially all other antibiotics (multidrug resistant) are being isolated from some hospitals in New York City with increasing frequency. A highly related pair of K. pneumoniae strains isolated on the same day from one patient in a hospital in New York City were studied for antibiotic resistance. One (KP-2) was resistant t...

Infectious diseases are one of the leading causes morbidity and mortality worldwide, antibacterial resistance exacerbates situation. So this study aimed to investigate genes responsible for folate inhibitor pathway antagonists outer membrane protein among gentamicin-resistant K.pneumoniae isolates. The results showed that out 481 specimens, 270 (56.13%) bacterial growth versus 211 (43.87%) no g...