c-Kit mutations are frequently detected in mucosal melanomas, but their clinical significance in metastatic oral mucosal melanomas (OMM) remains unclear. The main purpose of this study was to investigate the clinical and pathological features of metastatic OMMs with c-Kit mutations and the efficiency of the tyrosine kinase inhibitor imatinib in treating metastatic OMMs. We found thatresidual pr...

We have isolated an outer mitochondrial membrane (OMM) fraction from baker's yeast. Saccharomyces cerevisiae, that possesses porin activity and contains a major polypeptide of 29,000 daltons. By analogy to similar data for an OMM fraction from rat liver and mung bean [Zalman, L. S., Nikaido, N. & Kagawa, Y. (1980) J. Biol. Chem. 255, 1771-1774], the 29,000-dalton polypeptide of the isolated yea...

Oral mucosal melanoma (OMM) is a fatal sarcoma of unknown etiology. Histological morphology and genetic events are distinct from those of its cutaneous counterpart. Mutation and up-regulation of c-kit has been identified in OMM which may activate downstream molecules such as RAS and RAF. These molecules are involved in the mitogen-activated protein kinase (MAPK) pathway leading to tremendous ce...

The aim of the present study was to find the effects of pre and post vitrification taxol treatment on bovineimmature cumulus oocyte complexes (COCs). Bovine ovaries were collected from the local slaughterhousein a container with 30-37°C physiologic saline and supplemented with antibiotics. The grade A aspiratedCOCs were assigned to 6 experimental groups; The 1st group was control (n=100) in whi...

Role-based access control (RBAC) provides flexibility to security management over the traditional approach of using user and group identifiers. In RBAC, access privileges are given to roles rather than to individual users. Users acquire the corresponding permissions when playing different roles. Roles can be defined simply as a label, but such an approach lacks the support to allow users to aut...

Software development organizations are often deterred from introducing product line architectures by the lack of simple, ready-to-use methods for developing and applying them. The well-known, published product-line-engineering methods tend to focus on the early stages of the software life cycle and address product line issues at a high-level of abstraction. Connecting product-line concepts with...

Unternehmenssoftware wächst beständig in Größe und Komplexität, weshalb es immer wichtiger wird, SoftwareentwicklungsParadigmen anzuwenden, die ein großes Problem abstrahieren und in kleinere Teile zerlegen können (divide and conquer). Die Modellgetriebene und komponentenbasierte Entwicklung ermöglichen genau dies, sie werden bisher allerdings, auf Grund ihrer getrennten Entwicklungsgeschichte ...

Myoglobin (Mb) interaction with the outer mitochondrial membrane (OMM) promotes oxygen (O2) release. However, comprehensive molecular details on specific contact regions of OMM oxygenated (oxy-) and deoxygenated (deoxy-)Mb are missing. We used dynamics (MD) simulations to explore oxy- deoxy-Mb lipids in two lipid compositions: (a) a typical whole average, (b) specifically cardiolipin-enriched c...

the aim of the present study was to find the effects of pre and post vitrification taxol treatment on bovineimmature cumulus oocyte complexes (cocs). bovine ovaries were collected from the local slaughterhousein a container with 30-37°c physiologic saline and supplemented with antibiotics. the grade a aspiratedcocs were assigned to 6 experimental groups; the 1st group was control (n=100) in whi...

The oral minimal model (OMM) has been proposed and validated at individual level [1] to estimate after an oral glucose perturbation the rate of appearance of glucose (Ra) and the insulin sensitivity (SI). As commonly done in metabolic modeling, the OMM parameters are estimated by weighted nonlinear least square (WNLS) separately in each subject. Due to the complexity of the model, parameter pre...