نتایج جستجو برای: oligodendrocyte precursor cells

تعداد نتایج: 1430626  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Ken Arai Eng H Lo

We show that cerebral endothelial cells secrete trophic factors that support the survival and proliferation of rat oligodendrocyte precursor cells (OPCs). This OPC-supportive phenomenon was mediated by Akt and Src signaling pathways. Noncytotoxic levels of oxidative stress downregulate trophic factor production and disrupt the ability of cerebral endothelial cells to support OPCs. These data su...

Journal: :Neuron 2010
Xianghui Zhao Xuelian He Xiaolei Han Yang Yu Feng Ye Ying Chen ThaoNguyen Hoang Xiaomei Xu Qing-Sheng Mi Mei Xin Fan Wang Bruce Appel Q. Richard Lu

MicroRNAs (miRNAs) regulate various biological processes, but evidence for miRNAs that control the differentiation program of specific neural cell types has been elusive. To determine the role of miRNAs in the formation of myelinating oligodendrocytes, we selectively deleted a miRNA-processing enzyme, Dicer1, in oligodendrocyte lineage cells. Mice lacking Dicer1 display severe myelinating defic...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Mark R Kotter Wen-Wu Li Chao Zhao Robin J M Franklin

Demyelination in the adult CNS can be followed by extensive repair. However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions is often inhibited by unknown factors. In this study, we test whether myelin debris, a feature of demyelinated lesions and an in vitro inhibitor of oligodendrocyte precursor differentiation, affects remyelination...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Ninel Gregori Christoph Pröschel Mark Noble Margot Mayer-Pröschel

We have found that the tripotential glial-restricted precursor (GRP) cell of the embryonic rat spinal cord can give rise in vitro to bipotential cells that express defining characteristics of oligodendrocyte-type-2 astrocyte progenitor cells (O2A/OPCs). Generation of O2A/OPCs is regulated by environmental signals and is promoted by platelet-derived growth factor (PDGF), thyroid hormone (TH) and...

Journal: :Methods in molecular biology 2006
Nathalie Billon Christine Jolicoeur Martin Raff

Oligodendrocytes develop from proliferating oligodendrocyte precursor cells (OPCs), which arise in germinal zones, migrate throughout the developing white matter and divide a limited number of times before they terminally differentiate. Thus far, it has been possible to purify OPCs only from the rat optic nerve, but the purified cells cannot be obtained in large enough numbers for conventional ...

Journal: :Brain : a journal of neurology 2000
G Wolswijk

One of the hallmarks of the human demyelinating disease multiple sclerosis is the inability to compensate adequately for the loss of myelin and of oligodendrocytes, the myelin-forming cells of the CNS. Oligodendrocyte precursor cells, a potential source of oligodendrocytes, have been identified in lesions of chronic multiple sclerosis, but it is not known whether they develop into new, fully di...

2014
Constantin Gonsior Fabien Binamé Carsten Frühbeis Nina M. Bauer Peter Hoch-Kraft Heiko J. Luhmann Jacqueline Trotter Robin White

Oligodendrocytes are the myelinating glial cells of the central nervous system. In the course of brain development, oligodendrocyte precursor cells migrate, scan the environment and differentiate into mature oligodendrocytes with multiple cellular processes which recognize and ensheath neuronal axons. During differentiation, oligodendrocytes undergo dramatic morphological changes requiring cyto...

2012
Jenea M. Bin Soo Yuen Leong Sarah-Jane Bull Jack P. Antel Timothy E. Kennedy

Current in vitro models to investigate the consequence of oligodendrocyte-specific loss-of-function mutations on myelination are primarily limited to co-culture experiments, which do not accurately recapitulate the complex in vivo environment. Here, we describe the development of an in vitro model of myelination and myelin maintenance in which oligodendrocyte precursor cells are transplanted in...

Journal: :Nature communications 2016
Hyun-Jeong Yang Anna Vainshtein Galia Maik-Rachline Elior Peles

While the formation of myelin by oligodendrocytes is critical for the function of the central nervous system, the molecular mechanism controlling oligodendrocyte differentiation remains largely unknown. Here we identify G protein-coupled receptor 37 (GPR37) as an inhibitor of late-stage oligodendrocyte differentiation and myelination. GPR37 is enriched in oligodendrocytes and its expression inc...

Journal: :The Journal of biological chemistry 2004
Xiao-Ying Cui Qi-Dong Hu Meriem Tekaya Yasushi Shimoda Beng-Ti Ang Du-Yu Nie Li Sun Wei-Ping Hu Meliha Karsak Tanya Duka Yasuo Takeda Lian-Yun Ou Gavin S Dawe Feng-Gang Yu Sohail Ahmed Lian-Hong Jin Melitta Schachner Kazutada Watanabe Yvan Arsenijevic Zhi-Cheng Xiao

Neurons and glia in the vertebrate central nervous system arise in temporally distinct, albeit overlapping, phases. Neurons are generated first followed by astrocytes and oligodendrocytes from common progenitor cells. Increasing evidence indicates that axon-derived signals spatiotemporally modulate oligodendrocyte maturation and myelin formation. Our previous observations demonstrate that F3/co...

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