Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been proposed as a therapy for treatment of type 2 diabetes and obesity. Bioassay-guided fractionation of the MeOH extract of the leaves and stems of Symplocos paniculata (Thunb.) Miq. (Symplocaceae), using an in vitro PTP1B inhibitory assay, resulted in the isolation of three ursane-type triterpenes, ursolic acid (1), corosolic acid (2)...

Decoctions, macerations and fumigations of the stem bark and wood of Terminalia brownii 20 Fresen. are used in traditional medicine for fungal infections and as pesticides on field crops and in 21 traditional granaries in Sudan. In addition, T. brownii is commonly used for protecting wooden 22 houses and furniture. Therefore, using agar disc diffusion and macrodilution methods, eight extracts 2...

Apple (Malus × domestica) accumulates bioactive ursane-, oleanane-, and lupane-type triterpenes in its fruit cuticle, but their biosynthetic pathway is still poorly understood. We used a homology-based approach to identify and functionally characterize two new oxidosqualene cyclases (MdOSC4 and MdOSC5) and one cytochrome P450 (CYP716A175). The gene expression patterns of these enzymes and of pr...

Plant triterpenoids represent a large and structurally diverse class of natural products. A growing interest has been focused on triterpenoids over the past decade due to their beneficial effects on human health. We show here that these bioactive compounds are major constituents of several aerial parts (floral bud, leaf bud, stem, and leaf) of olive tree, a crop exploited so far almost exclusiv...

Pentacyclic triterpenes (1) and (2) have been isolated from Mimusops elengi and assigned structures 3beta,6beta,19alpha,23-tetrahydroxy-urs-12-ene and 1beta-hydroxy-3beta-hexanoyllup-20 (29)-ene-23, 28-dioic acid, respectively, on the basis of spectroscopic studies including 2D-NMR. The compound 1 showed moderate inhibiting activity against beta-glucuronidase enzyme

As Heftmann, Bennett, and Bonner have indicated (l), considerable information has accumulated concerning the biosynthesis of sterols in animals (2) and fungi (3), yet practically nothing is known about the biogenesis of typically higher plant sterols or the numerous pentacyclic triterpenes that are widely distributed throughout the plant kingdom. As yet, it cannot be assumed that the over-all b...

BACKGROUND The Combretum leprosum Mart. plant, popularly known as mofumbo, is used in folk medicine for inflammation, pain and treatment of wounds. From this species, it is possible to isolate three triterpenes: (3β, 6β, 16β-trihydroxylup-20(29)-ene) called lupane, arjunolic acid and molic acid. In this study, through preclinical tests, the effect of lupane was evaluated on the cytotoxicity and...

Pentacyclic triterpenes from leaves of Cagaita (Eugenia dysenterica)Cristian A. Gasca, Matheus Chaves, Christopher W. Fagg, Pérola de Oliveira e Magalhães, Yris M. Fonseca-Bazzo, Dâmaris Silveira

Four dammarane-type, three lupane-type, and an oleanane-type triterpenes named foliasalacins A(1) (1), A(2) (2), A(3) (3), A(4) (4), B(1) (5), B(2) (6), B(3) (7), and C (8) were isolated from the leaves of Salacia chinensis LINN. collected in Thailand. The structures of new triterpene constituents (1-8) were characterized on the basis of chemical and physiochemical evidence.