Brain derived neurotrophic factor (BDNF) has been shown to exert trophic effects on dopaminergic neurons against 6-hydroxydopamine (6-OHDA) in young rat. Since the degeneration of substantia nigra dopaminergic neurons that occurs in Parkinson's disease is more often than not confined to elderly individuals, it is of interest to determine whether the effects of BDNF against 6 hydroxydopamine (6-...

Mild stress can protect against a larger insult, a phenomenon termed preconditioning or tolerance. To determine if a low intensity stressor could also protect cells against intense oxidative stress in a model of dopamine deficiency associated with Parkinson disease, we used methamphetamine to provide a mild, preconditioning stress, 6-hydroxydopamine (6-OHDA) as a source of potentially toxic oxi...

In this study, we developed a miniaturized microfluidic-based high-throughput cell toxicity assay to create an in vitro model of Parkinson's disease (PD). In particular, we generated concentration gradients of 6-hydroxydopamine (6-OHDA) to trigger a process of neuronal apoptosis in pheochromocytoma PC12 neuronal cell line. PC12 cells were cultured in a microfluidic channel, and a concentration ...

Parkinson's disease (PD) is a disorder characterized by the degeneration of certain neuronal populations in the central and peripheral nervous system. One of the hallmarks of the disease is the toxic accumulation of proteins within susceptible neurons due to major impairment in the degradation/clearance protein systems.RTP801 is a pro-apoptotic protein that is sufficient and necessary to induce...

Abstract: Aim/Background: Parkinson’s Disease (PD), the loss of dopaminergic neurons in substantial nigra part brain leading to neurodegeneration. Materials and Methods: The objective this study was observe neuroprotective effect synthesized derivatives 6-hydroxydopamine (6-OHDA) induced rat model. Here, designed naphthalene substituted azetidinone compounds defended lesions caused by 6-OHDA mo...

abstractintroduction: parkinson's disease (pd) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. therefore, its neuroprotective effect in a model of parkinson’s disease in rat was evaluated.meth...

Parkinson’s disease (PD) is neurodegenerative disease, which accompanied by degeneration of dopaminergic neurons in subtantia nigra. Non-motor symptoms, particular, disorders the gastrointestinal (GI) tract are observed 20-80% patients some 15-20 years before clinically diagnosed PD and not a least important feature pathogenesis. The transient receptor potential (TRP) channels expressed through...

Kazuo MIZUMOTO1), Yoshihiro NOSO1), Shigeru SAKANO2), Kanji FURUYA3) and Riruke MARUYAMA4) 1)Department of surgery, Ohda General Medicine Education Center, 1428-3 Ohda-cho, Ohda, Shimane 694-0063, Japan 2)Department of surgery, Ohda City Hospital, 1428-3 Ohda-cho, Ohda, Shimane 694-0063, Japan 3)Department of internal medicine, Ohda City Hospital, 1428-3 Ohda-cho, Ohda, Shimane 694-0063, Japan ...

AbstractIntroduction: Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefore, its neuroprotective effect in a model of Parkinson’s disease in rat was evaluated.Methods: ...