The concentration of oestrone in the cerebrospinal fluid (CSF) from obese young women with pseudotumour cerebri was much greater than predicted and found in normal subjects. Each woman with pseudotumour cerebri, and a high level of CSF oestrone and a CSF protein less than 0·2 g/l, had clinical improvement when treated with an 800 calorie/day diet and dexamethasone 2 mg/day.

were characterized by a rise of the levels associated with oestrus to a well-defined peak followed by a sudden decrease, usually to the lowest levels observed. After conception, the levels of oestrone were not appreciably different from those during the oestrous cycle until at the end of the 3rd week at which time the excretion of oestrone increased. The week of maximal oestrone excretion in th...

1. Oestrone 3-glucuronide has been identified as the reaction product after incubation of oestrone with a rabbit-liver microsomal preparation, uridine diphosphate glucuronic acid being used as the glucuronic acid donor. The formation of this compound was studied under various experimental conditions. 2. The reaction showed a maximum at pH 8.08-2, and Km for oestrone was found to be 9-7 x 10-5M....

Progesterone and oestrone alone or in combination were administered to sows during early gestation. A dose of 25 mg progesterone and 12-5 mug oestrone injected together for 10,5 or 2 consecutive days during the implantation interval caused increased litter size at term.

Between Days 9 and 15 after oestrus, concentrations of pregnenolone, pregnenolone sulphate, dehydroepiandrosterone (DHEA), DHEA sulphate, androstenedione, oestrone and oestrone sulphate in free uterine fluid collected from non-pregnant gilts were greater than respective values in plasma (P less than 0.05). The total contents of pregnenolone, progesterone, DHEA, testosterone, oestrone and oestra...

The first paper of this series (Roy, 1953) reported the presence of two distinct fractions exhibiting sulphatase activity in an aqueous extract of an acetone powder of ox liver, and gave preliminary data on the properties of the two crude enzymes, which were separated by fractional precipitation with acetone. The present paper describes the further purification and properties of fraction A, now...

We describe a 3 year old girl with the typical clinical features of the X linked recessive condition, Hunter's disease. The diagnosis was confirmed by the pattern of urinary excretion of glycosaminoglycans and the absence of iduronate sulphatase activity in her fibroblasts. She also had an apparently balanced reciprocal chromosomal translocation 46XX,t(X:5) with the X breakpoint being between q...

Microwave-assisted phospha-Michael addition reactions were carried out in the 13α-oestrone series. The exocyclic 16-methylene-17-ketones as α,β-unsaturated ketones reacted with secondary phosphine oxides nucleophilic partners. furnished two tertiary oxide diastereomers high yields. main product was 16α-isomer. antiproliferative activities of newly synthesised organophosphorus compounds against ...