Background and aims. Odontogenic cysts and tumors have a wide spectrum of clinical characteristics that lead to the different management strategies. Since definite diagnosis is difficult in some cases, it has been suggested that CD56 may be a candidate marker for definitive diagnosis of some odontogenic tumors. The present study was designed to examine CD56 expression in lesions with histopatho...

Odontogenic tumors and cysts, arising in the jawbones, grow by resorption and destruction of the jawbones. However, mechanisms underlying bone resorption by odontogenic tumors/cysts remain unclear. Odontogenic tumors/cysts comprise odontogenic epithelial cells and stromal fibroblasts, which originate from the developing tooth germ. It has been demonstrated that odontogenic epithelial cells of t...

UNLABELLED The practice of pathology is currently undergoing significant change, due to advances in the field of molecular pathology. Tumor markers are molecules that help the pathologists for confirmatory diagnosis of histopathologically confounding lesions. Odontogenic tumors are relatively rare with estimated incidence of less than 0.5 cases/ 100,000 population per year. Odontogenic tumors c...

central granular cell odontogenic tumor) cgcot) of the jaw is an exceedingly rare benign odontogenic neoplasm with 35 reported cases in the literature. among these, very few studies have focused on the cone-beam ct features of cgcot. here, we report a case of an asymptomatic cgcot in a 16-year-old girl and focus on the cone-beam ct features. only 36 cases of this lesion, including this one, hav...

The Odontogenic Keratocyst (OKC), first described by Phillipsen in 1956, has been reclassified as odontogenic neoplasm and has been renamed as Keratocystic Odontogenic Tumor (KCOT) as reported in WHO classification of head and neck tumors in 2005. Odontogenic keratocysts are benign intraosseous tumors of odontogenic origin that occur most commonly in the jaw. In particular, they have a predilec...

Odontogenic tumors comprise a range of disorders of growth, from malignant and benign neoplasms, to malformations of dental tissues of self-limited growth. They are principally jaw lesions but some may present as localized gingival swellings, so-called peripheral odontogenic tumors. The majority of odontogenic tumors are benign; however, some, typically (but not exclusively) ameloblastomas, sho...

Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differ...

Oral and maxillofacial pathology has paramount importance in connecting basic science and clinical features; progress in this field will improve diagnosis and treatment. Although the prevalence of odontogenic tumors varies in different geographic sites, there are no reports in English on the relative frequency of odontogenic tumors in Iran. In the present 30-year retrospective study, the case r...