Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease. Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). Here, we show that the therapeutic effect of OD, which was investigated both in vitro and chemically, induced HCC model. OD significantly enhanced apoptosis and antiproliferative activity and reduced m...

Adult offspring of severely diabetic pregnant rats are insulin resistant and display cardiovascular dysfunction. When pregnant they develop mild hyperglycaemia. Diets high in saturated fat have been implicated in the development of cardiovascular disease and vascular dysfunction. In the present study we have determined vascular function in small mesenteric arteries from offspring of normal (OC)...

Traffics of different regions in a city have different Origin-Destination (OD) patterns, which potentially reveal the surrounding traffic context and social functions. In this work, we present a visual analysis system to explore OD patterns of interested regions based on taxi trajectories. The system integrates interactive trajectory filtering with visual OD patterns exploration. Trajectories r...

Primary visual cortex (V1) is the site at which right and left eye pathways are first integrated, leading to a representation of the visual world in depth. The ocular dominance (OD) of individual cortical neurons varies and may be changed by altering visual experience during the developmental critical period. Estimates of OD, commonly used to quantify the right and left eye synaptic inputs, hav...

BACKGROUND The complexity of fibre distributions in tissues is an important microstructural feature, now measurable in vivo by magnetic resonance imaging (MRI) through orientation dispersion (OD) indices. OD metrics have gained popularity for the characterisation of neurite morphology, but they still lack systematic validation. This paper demonstrates a framework for whole-sample histological q...

In oocyte donation (OD) pregnancies, there is a higher level of antigenic dissimilarity between mother and fetus compared with naturally conceived (NC) pregnancies. We hypothesize that a higher degree and/or a different type of immunoregulation is necessary to maintain an uncomplicated OD pregnancy. Different immunological aspects of successful OD pregnancies (n=28) were compared with those of ...

Background The oral selective phosphodiesterase-4 inhibitor roflumilast (ROF) reduces exacerbations in patients with severe COPD. Adverse events (AEs) can cause early ROF discontinuation. Alternative dosing strategies may help patients continue their therapy. Methods In this multicenter, double-blind trial, 1,321 patients with severe COPD were randomized 1:1:1 to 4 weeks' treatment with ROF 2...

BACKGROUND normal ageing processes impact on oropharyngeal swallowing function placing older adults at risk of developing oropharyngeal dysphagia (OD). Anecdotal clinical experience has observed that older patients recovering from hip fracture surgery commonly develop OD post-operatively. OBJECTIVE to document the presence of OD following hip fracture surgery, and the factors associated with ...

OBJECTIVES The automotive industry represents the most important industrial sector in Czechia. The objective of this study has been to analyze the occurrence of occupational diseases (OD) in the automotive industry during the period from 2001 till 2014. MATERIAL AND METHODS Data on OD cases was retrieved from the National Registry of OD. Further, we conducted a survey in automotive companies ...