Address for Correspondence: Dr. Jyothirmay Biswas, Head of the Department of Ocular-Pathology and Uvea, Medical and Vision Research Foundations, Sankara Nethralaya, 18, College Road, Chennai-600 006, E-mail: [email protected] Toxoplasmosis is the most common cause of posterior uveitis in many parts of the world. Prevalence is more in tropical countries than cold areas. 1,2 It is caused by Toxopla...

The diagnosis of ocular toxoplasmosis is based most often on the presence of characteristic clinical findings, which include focal retinochoroiditis, an adjacent or nearby retinochoroidal scar, and moderate to severe vitreous inflammation. However, a variety of less common, "atypical" presentations may be unfamiliar to clinicians, delaying both diagnosis and treatment. Patients who are immunoco...

This study investigated whether polymorphisms of the MICA (major histocompatibility complex class I chain-related gene A) gene are associated with eye lesions due to Toxoplasma gondii infection in a group of immunocompetent patients from southeastern Brazil. The study enrolled 297 patients with serological diagnosis of toxoplasmosis. Participants were classified into two distinct groups after c...

Dear Editor: Acquired Toxoplasma gondii ocular infection usually presents with necrotizing retinochoroiditis with dense vitritis and vasculitis. Atypical disease has been observed in im-munocompromised states such as malignancy and AIDS 1 or after iatrogenic systemic 2 or local 3 immunosuppression. Intravitreal triamcinolone acetonide (TA) is used frequently by ophthalmologists for conditions l...

A large amount of research has been done on toxoplasmosis in the last 30 years, and the world-wide incidence of the infection, and its clinical manifestations, are recognized and documented in an extensive literature. New discoveries concerning the life-cycle of the organism (Frenkel, I970; Hutchison, Dunachie, Siim, and Work, I970) promise to solve many of the problems of the transmission of i...

PURPOSE To update the current concepts in ocular toxoplasmosis. METHODS Interpretation of recent publications, meeting information and personal experience. RESULTS Most important aspects related to transmision of the parasite and clinical presentation of the ocular disease are discussed. Special issues on diagnosis and therapy are also mentioned. CONCLUSION A correct knowledge of the epid...

A large amount of research has been done on toxoplasmosis in the last 30 years, and the world-wide incidence of the infection, and its clinical manifestations, are recognized and documented in an extensive literature. New discoveries concerning the life-cycle of the organism (Frenkel, I970; Hutchison, Dunachie, Siim, and Work, I970) promise to solve many of the problems of the transmission of i...

Aims: To determine whether mothers of children with congenital toxoplasmosis have chorioretinal lesions consistent with toxoplasmosis. Methods: Prospective cohort study. Ophthalmologists in our study have examined 173 children with congenital toxoplasmosis in a hospital outpatient setting. These children were referred to us by their primary care physicians. One hundred and thirty mothers of the...

The recently modified fluorescence inhibition test for antibodies to toxoplasmosis is safe and relatively simple to perform. It appears to detect antibodies early in the course of acute systemic infection but is less sensitive than either the dye test or hemagglutination test in detecting chronic infection. Although hemagglutinating antibodies develop later than dye test antibodies in the cours...

Ocular toxoplasmosis is a disease caused by the infection with Toxoplasma gondii through congenital or acquired routes. Once the parasite reaches the retina, it proliferates within host cells followed by rupture of the host cells and invasion into neighboring cells to make primary lesions. Sometimes the restricted parasite by the host immunity in the first scar is activated to infect another le...