PURPOSE To investigate the long-term outcome of keratolimbal allograft (KLAL) for the treatment of severe ocular surface disorders. DESIGN Retrospective, noncomparative case series. PARTICIPANTS Twenty patients (23 eyes) with severe ocular surface disorders. INTERVENTION Thirty-three KLAL procedures were performed. Ten patients (10 eyes) underwent KLAL in combination with other surgical p...

Mutilation in the facial region may significantly affect the self-image and personality of individuals. Prosthetic rehabilitation of facial defects could increase the quality of life, thereby encouraging the patients to build up their self-confidence to return to normal social life. Acceptable cosmetic results are often obtained through facial prosthesis. Recovery after the loss of an eye requi...

DESIGN: Single-arm, prospective registry from May 30, 2006, to May 30, 2010, at an ophthalmic oncology referral center with ambulatory care. A total of 95 eyes of 78 patients with unilateral or bilateral retinoblastoma were treated. The intervention was selective catheterization of the ophthalmic artery and injection of chemotherapy, usually melphalan with or without topotecan. Drug dosage was ...

BACKGROUND Taiwan is endemic for pyogenic liver abscess (PLA). Septic ocular or central nervous system (CNS) complications derived from PLA can result in catastrophic disability. We investigated the epidemiology and long-term prognosis of PLA patients with septic ocular or CNS complications over an 8-year period. METHODOLOGY/PRINCIPAL FINDINGS We extracted 21,307 patients with newly diagnosed...

Sjögren syndrome (SS) is a chronic autoimmune disease characterized by inflammation of salivary and lacrymal glands, causing oral ocular dryness [1]. The was named Swedish ophthalmologist Henrik Sjögren, who identified it in 1933. SS prevalence ranges between 0. 5 % 3 the more likely to affect females over 40 years old, especially menopause [2, 3]. It slowly progressing, non-life-threatening wi...

Traveling to high altitudes can expose the eye to reduced ambient cold and low-pressure environments. These conditions can affect the physiology of the eye and may result in ocular problems and visual disturbances. In this paper, ocular disorders related to high altitudes are briefly reviewed. Then, high-altitude ocular disorders are categorized in three parts: those related to dry and cold env...

The increased use of chemotherapeutic agents has resulted in longer cancer patient survival. Consequently the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Ocular toxicity induced by cancer chemotherapy includes a broad spectrum of disorders, reflecting the unique anatomical, physiological and biochemical features of the eye. ...

We compared a previously characterized herpes simplex type 1 alpha 0 deletion mutant, dlx3.1, which produced no functional ICP0, with its wild-type parental strain, KOS, during acute ocular infection of different host animals. Acute pathogenicity of the viral strains in NZ rabbits, Balb/c and A/J mice was evaluated by keratitis scores, ocular and trigeminal ganglionic viral titers, and host sur...