Despite numerous scientific efforts many challenges need to be overcome in the ocular delivery because eyes have special and complex anatomic structures. The main problem with the conventional dosage forms is poor ocular bioavailability due to minimum ocular residence time, because of various anatomical and pathophysiological barriers prevailing in the eye. For this reason, much effort has been...

The aim of the present study was to compare conventional radial keratotomy (RK) with minimally invasive RK (mini-RK) in terms of achieved incisional depth as well as the histopathologic changes in the rabbit corneal structures. Four conventional RK incisions were performed on the right eye and four mini-RK incisions were performed on the left eye of 12 Island rabbits using a centripetal cutting...

This paper presents a preliminary study of using psychometric tests when testing input devices with older people. An experiment with twelve older computer users evaluating three commonly used input devices (mouse, touch screen and tablet-with-stylus) in two common computer tasks (browsing and playing solitaire), preceded by a questionnaire and psychometric tests (Simple Reaction Time, Mini Ment...

A scleral contact lens lies on the sclera, not cornea, which differs from a rigid gas permeable (RGP) lens, and has shown successful clinical outcomes in patients unable to tolerate glasses or RGP lenses because of severely deformed cornea. In addition, forms tear film between cornea that stabilizes ocular surface could be useful therapeutic option. The mini-scleral is option for visual improve...

Conventional dry-coating method can cause problems like non-core, double-core, off-center, inlay, and cooking, caused by the core tablet supply system. Hence, dry coating is not as widely used as normal tablets. One-step dry-coating (OSDrC) technology is an innovative one to solve these problems. OSDrC technology, which does not require a separate manufacturing process for the core, can even us...

Background: Lichen planus is a common dermatological condition. Many treatment options have been discussed in literature, each with its own risk profile. Betamethasone pulse therapy is one of the effective therapies mentioned.The objective of this study was to find out whether oral betamethasone mini pulse therapy is effective in lichen planus.Methods: A total of 40 pat...

OBJECTIVE To investigate the effects of mirror therapy using a tablet PC for post-stroke central facial paresis. METHODS A prospective, randomized controlled study was performed. Twenty-one post-stroke patients were enrolled. All patients performed 15 minutes of orofacial exercise twice daily for 14 days. The mirror group (n=10) underwent mirror therapy using a tablet PC while exercising, whe...

Many systemic antimicrobials have been implicated to cause ocular adverse effects. This is especially relevant in multidrug therapy where more than one drug can cause a similar ocular adverse effect. We describe a case of progressive loss of vision associated with linezolid therapy. A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezo...

In vivo confocal microscopy (IVCM) is an emerging technology that provides minimally invasive, high resolution, steady-state assessment of the ocular surface at the cellular level. Several challenges still remain but, at present, IVCM may be considered a promising technique for clinical diagnosis and management. This mini-review summarizes some key findings in IVCM of the ocular surface, focusi...