The interstitial nucleus of Cajal (INC) is thought to be the "neural integrator" for torsional/vertical eye position and head posture. Here, we investigated the coordination of eye and head movements after reversible INC inactivation. Three-dimensional (3-D) eye-head movements were recorded in three head-unrestrained monkeys using search coils. INC sites were identified by unit recording/electr...

25 Retinal information is two-dimensional, whereas eye movements are three-dimensional. The 26 oculomotor system solves this degrees-of-freedom problem by constraining eye positions to zero 27 torsion (Listing’s law) and determining how eye velocities change with eye position (half-angle 28 rule). Here we test whether the oculomotor plant, in the absence of well-defined neural 29 commands, can ...

A recent theoretical investigation has demonstrated that three-dimensional (3-D) eye position dependencies in the geometry of retinal stimulation must be accounted for neurally (i.e., in a visuomotor reference frame transformation) if saccades are to be both accurate and obey Listing's law from all initial eye positions. Our goal was to determine whether the human saccade generator correctly im...

Smooth pursuit eye movements are driven by retinal motion and enable us to view moving targets with high acuity. Complicating the generation of these movements is the fact that different eye and head rotations can produce different retinal stimuli but giving rise to identical smooth pursuit trajectories. However, because our eyes accurately pursue targets regardless of eye and head orientation ...

Mutilation in the facial region may significantly affect the self-image and personality of individuals. Prosthetic rehabilitation of facial defects could increase the quality of life, thereby encouraging the patients to build up their self-confidence to return to normal social life. Acceptable cosmetic results are often obtained through facial prosthesis. Recovery after the loss of an eye requi...

Traveling to high altitudes can expose the eye to reduced ambient cold and low-pressure environments. These conditions can affect the physiology of the eye and may result in ocular problems and visual disturbances. In this paper, ocular disorders related to high altitudes are briefly reviewed. Then, high-altitude ocular disorders are categorized in three parts: those related to dry and cold env...

Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...

Background: Behcet syndrome is a recurrent inflammatory disorder that frequently involves the ocular system. The purpose of this study was to determine the frequency of ocular involvement in cases of Behcet's disease in Babol, north of Iran. Methods: From April 2003 to December 2009, 100 cases of behcet's disease who were admitted at the Department of Ophthalmology and Internal Medicine of Babo...