E/xtensive investigation of the uveal circulation and ocular blood flow has been carried out since the original work by Waller in 1856. A dynamic determination of the uveal blood flow without alteration of normal physiologic processes has been hampered by the complexity of the vascular supply and its inaccessibility. Several recent reviews" have summarized previous methods used. The significanc...

OBJECTIVE To investigate the ocular blood flow response to systemic nitric oxide synthase inhibition in patients with primary open-angle glaucoma. METHODS In 12 patients with glaucoma and 12 age-matched control subjects, subfoveal choroidal blood flow, optic nerve head blood flow, ocular fundus pulsation amplitude, intraocular pressure, and systemic hemodynamic parameters were measured at bas...

Trabeculectomy, despite producing an effective reduction in intraocular pressure, may not prevent continued visual field loss. This may be because of the presence of other factors in the pathogenesis of glaucoma. Vascular factors have been suggested as being particularly important. To study the effect of trabeculectomy on ocular blood flow the technique of ocular pulse analysis has been used to...

PURPOSE To determine the changes in blood flow in the cat retina after 1 hour of ischemia. METHODS Blood flow in the retina and choroid of adult cats anesthetized with chloralose, acepromazine, and halothane was measured using sequential injections of radioactively labeled microspheres. Ischemia was induced by elevation of intraocular pressure above systolic arterial pressure. Measurements we...

A wide variety of ocular diseases are associated with abnormalities in ocular circulation. As such, there is considerable interest in techniques for quantifying retinal blood flow, among which Doppler optical coherence tomography (OCT) may be the most promising. We present an approach to measure retinal blood flow in the rat using a new optical system that combines the measurement of blood flow...

Dear Editor, I read the article “Choroidal blood flow change in eyes with high myopia” by Yang and Koh [1] with great interest. The authors investigated pulsatile ocular blood f low and found it to be decreased in high myopia. I commend the authors for this well organized study and want to make some contributions. The eyeball is enlarged in high myopia. This enlargement provides a larger area o...