Copyright 2007 Exposure Assessment Solutions, Inc. 1 Originally published as Hewett, P.: Interpretation and Use of Occupational Exposure Limits for Chronic Disease Agents. in Occupational Medicine: State of the Art Reviews, 11(3) July-Sept (1996). This version differs slightly from the original version in that the text was slightly reorganized, original text was restored, original figures were ...

Objective: To define threshold limit values and legally binding occupational exposure limits. Data Sources: Review of suitable literature. Study Selection: Studies based on detailed descriptions and/or measurements of airborne allergenic dust, total allergens, or even key allergens were selected. Results: Prevalences of IgE-mediated sensitization and occupational asthma are related to the aeroa...

Occupational exposure limits for unstudied pharmaceutical synthetic intermediates are often established under the assumption that penultimate and near-ultimate intermediates have the same structure-activity and dose-response as the ultimate active pharmaceutical ingredient (API). This is seldom the case because moieties that render biological activity to the API are often protected or modified ...

In Britain, 14 carcinogenic agents and occupational circumstances currently account for 86% of estimated occupation attributable cancer. The future burden associated with these carcinogens has been forecast, using attributable fractions for forecast scenarios representing patterns of past and predicted future exposure, and exposure levels representing the introduction of new occupational exposu...

results the overall prevalence of occupational asthma was 9.7%. this rate was 13.8% in the exposed group. logistic regression analysis showed that even after adjustment for confounding factors, a significant correlation existed between the frequency of occupational asthma and exposure to the produced dust particles (p < 0.05). in addition, age, work experience, body mass index, cigarette smokin...

Occupational exposure limits have traditionally focused on preventing morbidity and mortality arising from inhalation exposures to individual chemical stressors in the workplace. While central to occupational risk assessment, occupational exposure limits have limited application as a refined disease prevention tool because they do not account for all of the complexities of the work and non-occu...

Occupational standards concerning allowable concentrations of chemical compounds in the ambient air of workplaces have been established in several countries worldwide. With the integration of the European Union (EU), there has been a need of establishing harmonised Occupational Exposure Limits (OEL). The European Commission Directive 95/320/EC of 12 July 1995 has given the tasks to a Scientific...

UNLABELLED Exposure to occupational noise may cause injuries to the inner ear, and the distortion product otoacoustic emissions (DPOAE) may identify initial auditory alterations, thus assisting NIHL early diagnosis. AIM The goal of this study was to evaluate DPOAE as a method to diagnose early physiopathological alterations caused by occupational noise exposure. STUDY DESIGN Transversal. ...