Bei einer stabilen klinischen Remission der rheumatoiden Arthritis (RA) unter biologischen krankheitsmodifizierenden antirheumatischen Medikamenten (bDMARDs) sollte eine Dosisreduktion vorgenommen werden. Kann anhand dopplersonografisch beurteilten Synovitisaktivität vorhergesagt werden, ob die bzw. ein Absetzen Medikation erfolgreich verlaufen wird? Dieser Frage ging dänisches Forscherteam nach.

Leptin's actions are mediated via the long form of its receptor, Ob-Rb, but access to this receptor on target cells is also influenced by truncated leptin receptor isoforms Ob-Ra and Ob-Re. Plasma leptin binding activity is primarily attributed to Ob-Re, which can restrict leptin passage to extravascular tissue. In this study we investigated whether plasma leptin binding activity changes from f...

Für die klinisch tätigen Rheumatolog*innen, ob in Praxis, Institutsambulanzen oder stationären Einrichtungen der Rheumatologie, ist rheumatoide Arthritis (RA) häufigste Erkrankung. Auch wenn es milde und gut auf Therapie ansprechende Formen gibt, so hat Erkrankung jedoch das Potenzial rasant gelenkzerstörend zu verlaufen. mit optimalem Einsatz von modernen Therapiestrategien medikamentösen Subs...

STRESZ CZE nIE Wstęp. Jed ną z en do pro tez bez ce men to wych jest en do pro te za Zweymülle ra (ZM). W Kli ni ce Or to pe dii i Trau ma to lo gii UM w Po zna niu zo sta ły wy ko na ne kom plek so we ba da nia kli nicz ne i ra dio lo gicz ne u 180 cho rych le czo nych ope ra cyj nie w la tach 1995-2004 z uży ciem tej en do pro te zy. Ma te riał i me to dy. Ma te riał sta no wi 180 cho rych (2...

The objectives of this study were 1) to describe maternal glucose and lipid kinetics and 2) to examine the relationships with infant birth weight in obese women with pregestational type 2 diabetes during late pregnancy. Using stable isotope tracer methodology and mass spectrometry, maternal glucose and lipid kinetic rates during the basal condition were compared in three groups: lean women with...

We determined whether ANP (atrial natriuretic peptide) concentrations, measured by radioimmunoassay, in the ANPergic cerebral regions involved in regulation of sodium intake and excretion and pituitary glad correlated with differences in sodium preference among 40 Wistar male rats (180-220 g). Sodium preference was measured as mean spontaneous ingestion of 1.5% NaCl solution during a test perio...

Leptin and its long form receptor, Ob-Rb, in the hypothalamus play a key function in regulating food intake and body weight. We demonstrate here that apolipoprotein D (Apo D), a lipocalin that is heavily expressed in brain, interacts specifically with the cytoplasmic portion of Ob-Rb but not the short form receptor, Ob-Ra. This finding is detected in yeast two-hybrid systems as well as in prote...

Growing evidence shows interrelations of psychological factors, neurological and immunological processes. Therefore, constructs like a balance of activities, the so called "occupational balance", could also have biological correlates. The aim of this study was to investigate potential associations between occupational balance, functioning, cytokines and C-reactive protein (CRP) in patients suff...

Ziel der sogenannte Treat-to-Target-Strategie bei rheumatoiden Arthritis (RA) ist die Remission oder zumindest niedrige Krankheitsaktivität innerhalb von 6 Monaten nach Therapiebeginn. Wird dieses nicht erreicht, muss medikamentöse Behandlung angepasst werden. Ein tschechisches Forscherteam untersuchte nun, ob das Treat-to-Target-Konzept in klinischen Praxis gegenüber Standardversorgung Vorteil...

Background Systemic inflammation is the main factor underlying secondary osteoporosis in patients with rheumatoid arthritis (RA). The JAK inhibitors, such as Tofacitinib (Tofa), can control systemic and have beneficial effects on bone various models. This might be due to direct microenvironment not exclusively based their anti-inflammatory function. Bone marrow adipocytes (BMAds) are abundant m...