This paper presents an electronic index service that was developed in the Grif editor by taking advantage of the hypertext facilities available in the system. Grif is a structured document editor based on the generic structure concept that supports both hierarchical structures and non hierarchical links. The active cross-reference within the Grif index makes activation and browsing through inde...

This paper presents an electronic index service that was developed in the Grif editor by taking advantage of the hypertext facilities available in the system. Grif is a structured document editor based on the generic structure concept that supports both hierarchical structures and non-hierarchical links. The active cross-reference within the Grif index makes activation and browsing through inde...

We developed an automated colorimetric method for the quantitative determination of p-aminophenol with a Cobas Mira analyzer. The procedure can be used for the biological monitoring of human exposure to aniline. An absorbed aniline dose is extensively oxidized to p-aminophenol, which is excreted in urine mainly as glucurono- and sulfo- conjugates. After enzymatic hydrolysis, we reacted the free...

The carcinogen aniline is negative in the Ames Salmonella mutagenicity assay. Aniline does, however, induce intrachromosomal recombination between repeated sequences in Saccharomyces cerevisiae, resulting in deletion (DEL) of intervening sequences. We have investigated whether the generation of oxidative free radical species by aniline and/ or its metabolites may be responsible for its recombin...

The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's antinociceptive effect in rodents via activation of TRPV1 in the central nervous system (CNS) has provided a potential strategy for developing novel analgesics. Here we validated this strategy by examining ...

2-p-substituted phenyl-2-benzimidazolo acetonitriles (1a-5a) were prepared by the reaction of benzimidazole , p-substituted benzaldehydes and Sodium cyanide. A series of 2-(α-p -Substituted phenyl-αbenzimidazolo) methyl benzoxazoles (1b-5b) were synthesized by the reaction of 2-p-substituted phenyl-2benzimidazolo acetonitrile(1a-5a) and o-aminophenol in presence of Conc. HCl. These compounds we...

The rotational constants and the nitrogen nuclear quadrupole coupling constants of cis-3-aminophenol and trans-3-aminophenol are determined using Fourier-transform microwave spectroscopy. We examine several J = 2 <-- 1 and 1 <-- 0 hyperfine-resolved rotational transitions for both conformers. The transitions are fit to a rigid rotor Hamiltonian including nuclear quadrupole coupling to account f...

We evaluated a new method for measurement of acetaminophen. From acetaminophen, acetate and p-aminophenol are enzymically produced, and the latter product is determined colorimetrically by reaction with o-cresol and ammoniacal copper sulfate. The method is rapid and precise, and results compare well with those by spectrophotometric and liquid-chromatographic techniques. Major metabolites of ace...