BACKGROUND The recent discovery of residing tendon stem/progenitor cells has triggered a growing interest in stem cells as a useful tool in tendon repair. Our knowledge of their involvement in naturally healing tendons is, however, sparse. The aim of this study was to identify and determine stem/progenitor cells in relation to different healing phases and regions in a rat model of Achilles tend...

nucleostemin (ns), a stem cell-abundant nucleolar protein, is critical for maintaining the self-renewal and proliferative properties of normal and cancerous stem cells. recent data suggests that ns signaling is important for proliferation of t-cells and leukemia cells. this study was conducted to verify the role of ns in pathogenesis and treatment of t-cell acute lymphocytic leukemia (t-all). o...

Mammalian nucleostemin (NS) is preferentially expressed in stem cells and acts to promote cell cycle progression. In plants, stem cell activities have to be terminated during flower development, and this process requires the activation of AGAMOUS (AG) gene expression. Here, a nucleostemin-like 1 gene, NSN1, is shown to be required for flower development in Arabidopsis. The NSN1 mRNA was found i...

objective: acorus calamus (a. calamus) has been used as a medicinal plant in asia for its effects on digestive system for the last 2000 years. to investigate the anti-cancer activity of rhizome of a. calamus, the ethanolic and methanolic extracts and essential oil of the rhizome were prepared and their effects were assessed on human gastric cancer cell line (ags). materials and methods: the via...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 5 827–839 www.jcb.org/cgi/doi/10.1083/jcb.200812121 JCB 827 Q. Zhu and L. Meng contributed equally to this work. Correspondence to Robert Y.L. Tsai: [email protected] Abbreviations used in this paper: ALT, alternative lengthening of telomeres; APB, ALT-associated PML body; coIP, coimmunoprecipitation; EMSA, electrophoretic mo...

Myo6 gets choosy timulated neurons that lack myo-sin VI (Myo6) fail to endocytose a subtype of glutamate receptors called AMPARs, report Osterweil et al. on page 329. However, the neurons do not have a general endocytosis defect, suggesting a role for Myo6 in specific endocytic events. Unlike other myosins, Myo6 moves toward the minus ends of actin filaments. Thus, in polarized cells or cell re...

Mammalian nucleostemin (NS) is a nucleolar guanosine triphosphate-binding protein implicated in cell cycle progression, stem cell proliferation, and ribosome assembly. Drosophila melanogaster contains a four-member nucleostemin family (NS1-4). NS1 is the closest orthologue to human NS; it shares 33% identity and 67% similarity with human NS. We show that NS1 has intrinsic GTPase and ATPase acti...