BACKGROUND The significance of nontuberculous mycobacteria (NTM) isolated from a patient during therapy for pulmonary tuberculosis (TB) is uncertain. We investigated the frequency and clinical significance of NTM isolated from patients receiving anti-TB treatment. METHODS We conducted a retrospective cohort study of all patients with culture-confirmed pulmonary TB, and identified patients wit...

The prevalence of lung disease due to infections with nontuberculous mycobacteria (NTM) has been increasing and surpassed tuberculosis (TB) in some countries. Treatment outcomes are often unsatisfactory, highlighting an urgent need for new anti-NTM medications. Although NTM in general do not respond well to TB specific drugs, the similarities between NTM and Mycobacterium tuberculosis at the mo...

Non-tuberculous mycobacterium (NTM) account for 13% of cystic fibrosis (CF)-related respiratory infections and present a major therapeutic challenge. There is increasing evidence to suggest an adverse prognostic significance of NTM, particularly for Mycobacterium abscessus. A recent large retrospective study of 1216 patients with CF found that growths of NTM were associated with progressive det...

BACKGROUND Non-tuberculous mycobacteria (NTM) can cause pulmonary infection and disease especially among people living with HIV (PLHIV). PLHIV with NTM disease may clinically present with one of the four symptoms consistent with tuberculosis (TB). We describe the prevalence of NTM and Mycobacterium tuberculosis complex (MTBC) isolated among PLHIV who presented for HIV care and treatment. METH...

Nontuberculous mycobacteria (NTM) frequently detected in drinking water (DW) include species associated with human infections, as well as species rarely linked to disease. Methods for improved the recovery of NTM DNA and high-throughput identification of NTM are needed for risk assessment of NTM infection through DW exposure. In this study, different methods of recovering bacterial DNA from DW ...

Abstract Respiratory infections caused by non‐tuberculous mycobacteria (NTM) are a major cause of morbidity for patients living with cystic fibrosis (CF), as NTM pulmonary disease (NTM‐PD) is challenging to both diagnose and eradicate. Despite the lengthy courses established regimens recommended Cystic Fibrosis Foundation (CFF) European Society (ECFS) consensus guidelines, only about 50% 60% ac...

Mycobacterial lung disease is caused by nontuberculous mycobacteria (NTM), also known as atypical mycobacteria. NTM are widely distributed in the environment, particularly in soil and water. Although generally of low pathogenicity to humans, NTM can affect patients with underlying chronic lung diseases, such as cystic fibrosis, bronchiectasis, pneumoconiosis, or healed tuberculosis. Some patien...

Nontuberculous mycobacteria (NTM) are a large, diverse group of ubiquitous environmental organisms found in tap water, soil, dust, plants, animals, and food. NTM infection can cause various diseases, such as pulmonary disease (PD), which are most frequently observed in immunocompromised individuals. Diseases associated with NTM are particularly severe in those receiving tumor necrosis factor (T...

BACKGROUND Co-existence or subsequent isolation of multiple nontuberculous mycobacteria (NTM) species in same patient has been reported. However, clinical significance of these observations is unclear. The aim of this study was to determine clinical implications of changes of NTM species during or after treatment in patients with NTM lung disease. METHODS Patients with NTM lung disease, who e...

BACKGROUND Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms. Patients with pre-existing lung damage are susceptible to NTM, but their prevalence in bronchiectasis is unknown. Distinguishing between lung colonisation and disease can be difficult. METHODS A prospective study of 100 patients with bronchiectasis was undertaken to evaluate the prevalence of NTM in sputum, ...