نتایج جستجو برای: nrf2

تعداد نتایج: 8462  

Journal: :American journal of respiratory and critical care medicine 2009
Hye-Youn Cho Farhad Imani Laura Miller-DeGraff Dianne Walters Guillermina A Melendi Masayuki Yamamoto Fernando P Polack Steven R Kleeberger

RATIONALE Respiratory syncytial virus (RSV) is the most frequent cause of significant lower respiratory illness in infants and young children, but its pathogenesis is not fully understood. The transcription factor Nrf2 protects lungs from oxidative injury and inflammation via antioxidant response element (ARE)-mediated gene induction. OBJECTIVES The current study was designed to determine the...

2005
Andy Y. Shih Ping Li Timothy H. Murphy

The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) coordinates expression of genes required for free radical scavenging, detoxification of xenobiotics, and maintenance of redox potential. Previously, activation of this pleiotropic response was neuroprotective in cell culture models that simulate components of stroke damage. However, the role of Nrf2 in limiting stroke d...

2013
Dénes Türei Diána Papp Dávid Fazekas László Földvári-Nagy Dezső Módos Katalin Lenti Péter Csermely Tamás Korcsmáros

NRF2 is the master transcriptional regulator of oxidative and xenobiotic stress responses. NRF2 has important roles in carcinogenesis, inflammation, and neurodegenerative diseases. We developed an online resource, NRF2-ome, to provide an integrated and systems-level database for NRF2. The database contains manually curated and predicted interactions of NRF2 as well as data from external interac...

2012
Kai Connie Wu Julia Yue Cui Curtis D. Klaassen

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol. The purpose of this study was to investigate the role of Nrf2 in regulating the mRNA of genes encoding drug metabolizing enzymes and xenobiotic trans...

2014
Yoko Yagishita Toshiaki Fukutomi Akira Sugawara Hiroshi Kawamura Tetsu Takahashi Jingbo Pi Akira Uruno Masayuki Yamamoto

Transcription factor Nrf2 (NF-E2–related factor 2) regulates wide-ranging cytoprotective genes in response to environmental stress. Keap1 (Kelch-like ECH–associated protein 1) is an adaptor protein for Cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. The Keap1-Nrf2 system plays important roles in the oxidative stress response and metabolism. However, the roles Nrf2 plays in prev...

Journal: :Molecular cell 2013
Nicole F Villeneuve Wang Tian Tongde Wu Zheng Sun Alexandria Lau Eli Chapman Deyu Fang Donna D Zhang

Nrf2 is a master regulator of the antioxidant response. Under basal conditions, Nrf2 is polyubiquitinated by the Keap1-Cul3 E3 ligase and degraded by the 26S proteasome. In response to Nrf2 inducers there is a switch in polyubiquitination from Nrf2 to Keap1. Currently, regulation of the Nrf2-Keap1 pathway by ubiquitination is largely understood. However, the mechanism responsible for removal of...

Journal: :Toxicon 2021

Deoxynivalenol (DON) commonly infects agricultural foods; it exhibits toxicity by inducing oxidative stress and inhibiting protein synthesis. Nuclear factor erythroid 2-related 2 (NRF2) regulates the cellular antioxidant response. We investigated cytotoxicity of DON its effect on NRF2 response in HepG2 cells. The Methyl Thiazol Tetrazolium (MTT), glutathione (GSH) ATP assays evaluated toxicity,...

Journal: :Diabetes 2014
Yoko Yagishita Toshiaki Fukutomi Akira Sugawara Hiroshi Kawamura Tetsu Takahashi Jingbo Pi Akira Uruno Masayuki Yamamoto

Transcription factor Nrf2 (NF-E2-related factor 2) regulates wide-ranging cytoprotective genes in response to environmental stress. Keap1 (Kelch-like ECH-associated protein 1) is an adaptor protein for Cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. The Keap1-Nrf2 system plays important roles in the oxidative stress response and metabolism. However, the roles Nrf2 plays in prev...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Andy Y Shih Ping Li Timothy H Murphy

The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) coordinates expression of genes required for free radical scavenging, detoxification of xenobiotics, and maintenance of redox potential. Previously, activation of this pleiotropic response was neuroprotective in cell culture models that simulate components of stroke damage. However, the role of Nrf2 in limiting stroke d...

2010
Wenge Li Nehal Thakor Eugenia Y. Xu Ying Huang Chi Chen Rong Yu Martin Holcik Ah-Ng Kong

Nrf2 plays pivotal roles in coordinating the antioxidant response and maintaining redox homeostasis. Nrf2 expression is exquisitely regulated; Nrf2 expression is suppressed under unstressed conditions but strikingly induced under oxidative stress. Previous studies showed that stress-induced Nrf2 up-regulation results from both the inhibition of Nrf2 degradation and enhanced Nrf2 translation. In...

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