The drug interaction between new quinolone antibiotics (NQs) and polyvalent metal cation products, leading to a significant decrease in the absorption of NQ, is considered to be attributable to the formation of poorly absorbable chelate and physicochemical adsorption of NQs to cation products. To clarify the mechanisms of this drug interaction in detail, we investigated the effects of Al(3+) or...

New selective and sensitive spectrophotometric and spectrofluorometric methods have been developed and validated for the determination of amantadine hydrochloride (AMD) in capsules and plasma. The methods were based on the condensation of AMD with 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium to form an orange-colored product. The spectrophotometric method involved the measurement...

New simple and sensitive spectrophotometric and fluorimetric methods have been developed and validated for the determination of fluoxetine hydrochloride (FLX) in its pharmaceutical formulations. The spectrophotometric method was based on the reaction of FLX with 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium (pH 11) to form an orange-colored product that was measured at 490 nm. The...

This paper presents criteria for the onset of NQS effects derived from time transient device simulations and Sparameter measurements. For the first time it has been proved that e.g. a 10μm NMOS transistor can be described up to 27MHz and a 0.2μm device up to 46GHz by the quasistatic approach while the accuracy of the description of the inversion layer charge is still 99%. Introduction Due to co...

One of the advantages of SOI transistors compared to bulk devices is that at GHz frequencies, the substrate does not impact significantly on the behavior of transistors. Thanks to the thickness of the buried oxide, the body effect can be safely neglected at high frequency [4.1]. Thus, it is not necessary to develop a four terminal model for the SOI transistor used for RF applications. In this c...

Two simple, specific, accurate, precise, sensitive and cost effectivespectrophotometric methods have been developed and validated for quantification oflinagliptin in pure form and pharmaceutical formulations. Method A is established onthe computation of absorbance of purple coloured chromogen complex at 463 nmwhich is formed by the condensation reaction of the primary amine group oflinagliptin ...

Neural network quantum states (NQS) have been widely applied to spin-1/2 systems where they proven be highly effective. The application with larger on-site dimension, such as spin-1 or bosonic systems, has explored less and predominantly using Restricted Boltzmann Machines (RBMs) a one-hot/unary encoding. Here we propose more direct generalisation of RBMs for that retains the key properties sta...

The X-ray free-electron lasers that became available during the last decade, like European XFEL (EuXFEL), place high demands on their instrumentation. Especially at low photon energies below 1 keV, detectors with sensitivity, and consequently noise quantum efficiency, are required to enable facility users fully exploit scientific potential of source. A 1-Megapixel pnCCD detector a 1024 × pixel ...

A new application of the mean centering of ratio spectra method is proposed for estimation of the rate constants of second order reactions, using kinetic-spectrophotometric data. The method is based on the mean centering of the ratio spectra to obtain a kinetic profile of the product. Using computational fitting, the rate constant can be obtained without any ambiguity. An interesting feature of...