This study aimed to investigate the proportions of morphine, thebaine, noscapine, codeine, oripavine and papaverine alkaloids in poppy varieties hybrids. Nine parents 36 hybrid lines were used trial. The trial was carried out 2016 2017 four replications according Randomized Block Trial Design. According average results two years, parent combinations, morphine found vary between 0.42% 1.66%, the...

abstract background: it has been demonstrated that noscapine, an antitussive opioid alkaloid, could antagonize bradykinin- induced responses such as bradykinin effects in guinea-pig ileum, cough induced by bradykinin receptor agonist and angiotensin converting enzyme inhibitors, and brain damage after brain edema both in neonatal rat model and in patients with stroke. in the present study, the ...

abstractin the present work we set out to investigate the neuroprotective effects of noscapine (0.5-2 µm) in presence of d-glucose on primary murine foetal cortical neurons after oxygen–glucose deprivation/24 hrs recovery. cell viability, nitric oxide production and intracellular calcium ([ca2+]i) levels were evaluated by mtt assay, the modified griess method and fura-2 respectively. 25 and 100...

objective(s): endometriosis is a complex gynecologic disease with unknown etiology. noscapine has been introduced as a cancer cell suppressor. endometriosis was considered as a cancer like disorder, the aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells in vitro. materials and methods:in this in vitro study, endometrial biopsie...

Systematic screening based on structural similarity of drugs such as colchicine and podophyllotoxin led to identification of noscapine, a microtubule-targeted agent that attenuates the dynamic instability of microtubules without affecting the total polymer mass of microtubules. We report a new generation of noscapine derivatives as potential tubulin binding anti-cancer agents. Molecular modelin...

We have previously identified the opium alkaloid noscapine as a microtubule interacting agent that binds stoichiometrically to tubulin and alters its conformation. Here we show that, unlike many other microtubule inhibitors, noscapine does not significantly promote or inhibit microtubule polymerization. Instead, it alters the steady-state dynamics of microtubule assembly, primarily by increasin...

The delivery of noscapine therapies directly to the site of the tumor would ultimately allow higher concentrations of the drug to be delivered, and prolong circulation time in vivo to enhance the therapeutic outcome of this drug. Therefore, we sought to design magnetic based polymeric nanoparticles for the site directed delivery of noscapine to invasive tumors. We synthesized Fe(3)O(4) nanopart...

Noscapine is an antitussive drug and possesses potent antitumor activity. This work establishes a highly sensitive method for its determination by flow injection chemiluminescence (CL) technique. This method is based on its strong sensitizing effect on the weak CL reaction between sulfite and acidic permanganate. The mechanism for the sensitizing process is proposed on the basis of fluorescence...

We have previously discovered the opium alkaloid noscapine as a microtubule interacting agent that binds to tubulin, alters the dynamics of microtubule assembly, and arrests mammalian cells at mitosis (Ye, K., Ke, Y., Keshava, N., Shanks, J., Kapp, J. A., Tekmal, R. R., Petros, J., and Joshi, H. C. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 1601-1606; Ye, K., Zhou, J., Landen, J. W., Bradbury, ...

BACKGROUND Massive ischemic stroke causes significant mortality and morbidity in stroke patients. The main treatments for massive ischemic stroke are recombinant tissue plasminogen activator (rtPA), craniotomy, and endovascular interventions. Due to destructive effects of bradykinin on the nervous system in ischemic stroke, it seems reasonable that using Noscapine as a Bradykinin antagonist may...