AIM The purpose of this study was to evaluate the influence of polymorphisms of the eNOS gene on the clinical status of patients with normal and high tension glaucoma. METHODS 266 Polish Caucasian patients with primary open angle glaucoma were studied. Of the 266, 156 had normal tension glaucoma (NTG) and 110 high tension glaucoma (HTG). DNA material was isolated from peripheral venous blood ...

Author Contributions: Conception and design: Pasquale, Hyman, Danias, Kang Data collection: Pasquale, Kang Analysis and interpretation: Pasquale, Hyman, Rosner, Joshipura, Danias, Kang Obtained funding: Not applicable Overall responsibility: Pasquale, Hyman, Wiggs, Rosner, Joshipura, McEvoy, McPherson, Danias, Kang Abbreviations and Acronyms: CI 1⁄4 confidence interval; HPFS 1⁄4 Health Professi...

Purpose. To determine whether the patterns of visual field damage between high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) are equivalent. Methods. In this retrospective cross-sectional study, fifty-one NTG and 57 HTG patients were recruited. For each recruited patient only the left eye was chosen. Glaucomatous patients had abnormal visual fields and/or glaucomatous changes at the ...

OBJECTIVE To determine the proportions of glaucoma subtypes and risk factors for glaucoma in a large Japanese American clinic population. METHODS Medical records of patients of Japanese descent who visited 2 private ophthalmology clinics within the last 10 years were retrospectively reviewed. Glaucoma was diagnosed based on optic nerve findings and presence of visual field defects. Main outco...

AIM The objective of our work was to determine whether there is a difference in fMRI activation between patients with high tension glaucoma (HTG) and those with normal tension glaucoma (NTG). METHOD The sample consisted of eight patients with different stages of high tension glaucoma (3 females aged 41-65 and 5 males aged 40-73 years) and eight patients, also with different stages of normal t...

PURPOSE Oxidative stress plays a critical role in the pathogenesis of glaucoma. Glutathione is a major antioxidant molecule present in intracellular or extracellular space. Herein, we aimed to examine circulating glutathione level in normal tension glaucoma (NTG), which comprises the largest proportion of glaucoma disease in the Korean population. METHODS Nineteen NTG patients (NTG group) and...

Glaucoma is a neurodegenerative disease of the optic nerve characterized by progressive loss of retinal ganglion cells (RGCs), which can lead to irreversible blindness. Numerous factors have been implicated in the disease, with high intraocular pressure (IOP), coupled with advanced age, being major risk factors. Other factors include ischemia, generation of reactive oxygen species, a genetic pr...

AIMS To investigate the usefulness of the scanning laser polarimeter (GDx; GDx Nerve Fiber Analyzer) for glaucoma detection in the Japanese population, and to investigate the difference in the thickness of retinal nerve fibre layer (RNFL) between normal tension glaucoma (NTG) and primary open angle glaucoma (POAG). METHODS 69 eyes of 69 normal subjects and 115 eyes of 115 chronic open angle g...

BACKGROUND Although elevated intraocular pressure is a major risk factor for the development of glaucoma, there is increasing evidence that the immune system may be involved in the development of normal-tension glaucoma (NTG). The aim of this study was to determine if NTG is associated with elevated levels of antibodies against human heat shock protein (HSP) 60. MATERIAL AND METHODS The study...

PURPOSE To compare choroidal thickness measurements among normal eyes, eyes with normal tension glaucoma (NTG), and those with primary open-angle glaucoma (POAG), and to correlate choroidal thickness with demographic and clinical ocular parameters. METHODS Choroidal thickness was measured with enhanced depth-imaging (EDI) optical coherence tomography (OCT) in one eye of 38 normal, 20 NTG, and...