OBJECTIVE To study the characteristics of peptic ulcer and erosion in pediatric patients. METHODS Over a period of seven years, 1,026 children underwent upper gastrointestinal endoscopy in our pediatric gastroenterology unit. RESULTS Peptic ulcers and erosions were found in 59 (7.2%) patients [ulcers in 42 (5.1%)and erosions in 17 (2.1%)]. Thirty (50.9%) children presented with acute upper ...

Withania somnifera, popularly known as Ashwagandha is widely considered to be an integral part of Ayurvedic and Indigenous medical systems for over centuries for the treatment of various ailments. Withanolides (steroid lactone), are the major active constituents present in the roots and leaves of Withania somnifera. In the present study, withaferin A (active component of Withania somnifera), a ...

BACKGROUND Gastric ulcers in fattening pigs from intensive pork production can cause sudden deaths on farm and the grinding intensity of the diet appears to be among the risk factors. The objective of this work is to adopt the latest laboratory tests and thresholds for the ulcerogenic risk assessment of diets from experimental reports and verify the class of risk in relation to gastric lesion p...

Although the ulcerogenic action of corticosteroids in the stomach is controversial, its action on ulcer healing has not been defined. In this study, we used non-ulcerogenic doses of dexamethasone (0.1 or 0.2 mg/kg/day) to explore the adverse effect on ulcer healing as well as its pathological mechanisms in rat stomach. In this regard, we measured ulcer size, mucus thickness, epithelial cell pro...

E SOPHAGOGASTRIC ulcers in swine have attracted the attention of swine producers and scientists in recent years because of their apparent increased frequency of occurrence or because of increased awareness of the condition. Various studies and surveys have shown from about 1% (Hoorens et al., 1965) to 55% (Perry et al., 1963) incidence of esophagogastric ulcers in swine. If one considers the va...

A novel series of 2-[3-(4-bromophenyl)propan-3-one]-5-(substituted phenyl)-1,3,4-oxadiazoles (4a-n) have been synthesized from 3-(4-bromobenzoyl)propionic acid (3) with the aim to get better anti-inflammatory and analgesic agents with minimum or without side effects (ulcerogenicity). Compound 3 was reacted with several aryl acid hydrazides (2a-n) in phosphorous oxychloride to obtain the title c...

Peptic ulcers are a broad term that includes ulcers of gastrointestinal tract. The formation of peptic ulcers is due to the presence of acid, peptic activity in gastric juice and a breakdown in mucosal defenses. There are two main factors that can disrupt the mucosal resistance to injuryare, nonsteroidal anti-inflammatory drugs and H. pylori infection. A number of anti-ulcer drugs such as proto...

The aerial part of Equisetum telmateia Ehrh. is used against various conditions including stomachache and peptic ulcer in Turkish folk medicine. In order to prove the claimed anti-ulcerogenic potential of the plant, aqueous and methanol extracts were prepared from aerial parts of E. telmateia and investigated for their anti-ulcerogenic effect on ethanol-induced gastric ulcer model in rats. Phar...

A series of 2-(substituted-phenyl)-5-(N,N-diphenylaminomethyl)-1,3,4-oxadiazoles (3-15) were synthesized. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. The percentage inhibition in edema at different time intervals indicated that compounds 8, 11, 12, 14 and 15 exhibited good anti-inflammatory potential. The results illustrate th...

A series of 2-thienyl-3-substitued indole derivatives (1-11) were synthesized. Their structures were established on the basis of elemental and spectral (IR, HNMR and Mass spectral data) studies. All the 1 synthesized compounds have been tested for their antitumor activity against breast cancer cell line (MCF-7) using doxorubicin as a standard drug (IC =2.97 μg/ml). Most of the prepared compound...