Background and objectivesRadiotherapy is the most crucial nonsurgical therapeutic method in multidisciplinary care of non-small cell lung cancer (NSCLC) patients. However, radiation resistance continues to be a significant clinical issue, negatively affecting prognosis The small molecules that target these RNAs offer modulation multiple biological processes. study aims identify genes long non-c...

Summary This year’s virtual version of the European Society for Medical Oncology (ESMO) presidential sessions included three “late breaking” non-small cell lung cancer (NSCLC) abstracts, discussing strategies adjuvant therapy localized disease and up-front treatment advanced anaplastic lymphoma kinase(ALK)-positive cancer.

The prevalence of and mortality due to lung cancer have been steadily increasing worldwide. Based on differences in treatment strategies, lung cancer can be classified as non-smallcell lung cancer (NSCLC) and small-cell lung cancer (SCLC). NSCLC mainly consists of adenocarcinoma and squamous cell carcinoma, comprising about 80% of the total lung cancer cases. The treatment strategy for NSCLC is...

Background: the aim of this study was to investigate the prognostic value of 18Fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) parameters in both overall survival and progression-free survival in Stage I-III non-small cell lung cancer (NSCLC). Materials and Methods: In this retrospective study, 267 patients who were diagnosed as Stage I-III non-smal...

Objective(s): Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (NSCLC) exhibit TRAIL-resistance. The purpose of this study was to determine whether subtoxic-dose cisplatin and TRAIL could synergistically enhance apoptosis on NSCLC cells and investigate its under...

biomolecular behavior of tumor cells has become attractive to investigators. p53 as an oncosuppresor gene has been core of various studies and ki67 is a nuclear protein involved in proliferation process. stopping of onco-suppressor function theoretically allows proliferative system to get out of any control. in this case-control study we evaluated 50 patients with non small cell lung cancer, co...

Background: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC). Chemotherapy resistance main cause chemotherapy failure. Cullin7 (Cul7) highly expressed in LUAD and associated with poor prognosis. Moreover, Cul7 abnormally overexpressed docetaxel-resistant cells. Therefore, further exploration role molecular mechanism docetaxel necessary.

introduction: growth, proliferation, survival, and differentiation are the prominent characteristics of cells, which are affected by cancer. epidermal growth factor receptor (egfr) plays a pivotal role in the effective control of these features. given the significance of egfr signaling pathway in non-small cell lung cancer (nsclc), egfr expression is influential on these cell characteristics. i...

Objective(s): To investigate the role of miR-22 in the efficacy of combined icotinib (BPI-2009H) and pemetrexed (LY-231514) on tumor growth and apoptosis in rats with non-small cell lung cancer (NSCLC).Materials and Methods: Rats were injected with HCC827 cells, which were transfected with anti-miR-22, followed by the treatment of BPI-20...