BACKGROUND Cadmium is a potent neurotoxic heavy metal, which induces oxidative stress and membrane disturbances in brain. Melatonin is an effective antioxidant and free radical scavenger against oxidative stress. The present study was designed to investigate the neuroprotective efficacy of melatonin in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), levels of l...

Formation of small and highly reactive oxygen species (ROS) is normal phenomena in living cells. The Reactive Oxygen Species cover free radical such as superoxide (O2 ̅ ), hydroxyl (OH), perhydroxy (HO2 ̅ ) and alkoxy (RO) and non-radicals like, hydrogen peroxide (H2O2) and singlet oxygen ( O2). Their formation and reactivity is well established and found to be tightly regulated. ROS level exceed...

Objectives: The study aims to estimate the changes in the serum levels of lipid peroxidation product malondialdehyde (MDA), non-enzymatic antioxidants: vitamin A, E and C and erythrocyte enzymatic antioxidants: superoxide dismutase (SOD) and catalase(CAT) in chronic alcoholic liver disease. Background: Alcohol consumption accounts for about 50% of patients death from end stage liver disease in ...

Free radicals play an important role in aging process and disease progression by damage to the cells. They have been implicated in the pathogenesis of various chronic and degenerative conditions including cancer, arthritis, aging, autoimmune disorders, cardiovascular and neurodegenerative diseases. Antioxidants are capable of deactivating free radicals before they attack human cells. In humans,...

Oxidative stress occurs when the body’s enzymatic or non-enzymatic antioxidants are outweighed by endogenous exogenous free radicals. radicals, reactive oxygen species, and other biomolecule-damaging radicals can be generated during normal cellular metabolism react with proteins, lipids, DNA. In domains of biology medicine, have become increasingly important. They accumulate in a variety ways, ...

The prevention of oxidation is an essential process in all cells, as decreased antioxidant protection may lead to cytotoxicity, mutagenicity and carcinogenicity. The mechanisms by which oxidative stress contributes to carcinogenesis include modulation of gene expression and induction of genetic modifications. Cellular methylation and antioxidant metabolism are linked by the transsulfuration pat...

There are a great number of reports with assertions that oxidative stress is produced by organophosphorus compound (OPC) poisoning and is a cofactor of mortality and morbidity in OPC toxicity. In addition, antioxidants have been suggested as adjuncts to standard therapy. However, there is no substantial evidence for the benefit of the use of antioxidants in survival after acute intoxication of ...

Drought is an important environmental constraint limiting the productivity of many crops worldwide. Experiments were conducted to investigate the effects of foliar spray of natural extract (garlic extract) on drought stress in two cultivars of soybean (Glycine max) plants. Drought stress caused significant decrease in growth parameters (shoot and root length, area of leaves, fresh and dry weigh...

We have evaluated the ameliorative effect of ginger extract on paraben (p-hydroxybenzoic acid)-induced lipid peroxidation in the liver of mice. Adult female albino mice were orally administered with 2.25 or 4.50 mg of paraben in 0.2 mL olive/animal/day (67.5 and 135 mg/kg of body weight) for 30 days. The results revealed significantly higher (p < or = 0.05) lipid peroxidation in the liver of pa...