AIM OF THE STUDY The aim of the study was to evaluate the effect and severity of liver diseases of different etiologies on the values of three non-invasive fibrosis markers. MATERIAL AND METHODS Serum samples from 65 patients with alcoholic cirrhosis, 31 with non-alcoholic cirrhosis and 32 with toxic hepatitis, were tested. Cirrhotic patients were classified according to the Child-Pugh scale....

BACKGROUND & AIMS The diagnosis of non-alcoholic steatohepatitis and fibrosis staging are central to non-alcoholic fatty liver disease assessment. We evaluated multiparametric magnetic resonance in the assessment of non-alcoholic steatohepatitis and fibrosis using histology as standard in non-alcoholic fatty liver disease. METHODS Seventy-one patients with suspected non-alcoholic fatty liver ...

Background The rate of hospital admissions for cirrhosis increased 1.3-fold during 2008–2016 in Queensland. Alcohol misuse was a contributing factor 55% and 40% patients had at least one comorbidity. Aims To examine the temporal change aetiology liver disease presence comorbidity admitted with cirrhosis. Methods Population-based retrospective cohort study all people treated (10 254 patients) Qu...

metabolome analysis is used to evaluate the characteristics and interactions of low molecular weight metabolites under a specific set of conditions. in cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (nafld) and non-alcoholic steatotic hepatitis (nash) the  liver  does not function thoroughly due to long-term damage. unfortunately the early detection of cirrhosis, hcc, na...

Primary liver cancer (hepatocellular carcinoma, HCC) is the fifth most common cancer in men and the seventh in women worldwide. It rarely occurs before the age of 40 years and reaches its peak incidence at approximatively 70 years of age. Major risk factors for HCC include: infection with hepatitis B (HBV) or hepatitis C (HCV), alcoholic liver disease, non-alcoholic fatty liver disease and less...

ALTHOUGH its histological features had long been recognized (1). the term non-alcoholic steatohepatitis (NASH) was first used by Ludwig et al. as recently as 1980 (2). Although it is commonly encountered in hepatology outpatient (office) practice (3). surprisingly little attention has been paid to NASH. It will be the purpose of this review to examine the clinical and pathological features of N...

Globally, an estimated one million deaths occur annually due to complications of cirrhosis. Cirrhosis with end stage liver disease [ESLD] is a leading cause death noncommunicable diseases in Sri Lanka. Non-alcoholic fatty [NAFLD] and alcohol related [ARLD] are the principal causes ESLD cirrhosis Liver transplantation remains only curative treatment for such patients. Multiorgan dysfunction hemo...

BACKGROUND Cystic fibrosis-related liver disease (CFLD) is present in up to 30% of cystic fibrosis patients and can result in progressive liver failure. Diagnosis of CFLD is challenging. Non-invasive methods for staging of liver fibrosis display an interesting diagnostic approach for CFLD detection. AIM We evaluated transient elastography (TE), acoustic radiation force impulse imaging (ARFI),...

BACKGROUND Alcoholic hepatitis is associated with altered hepatic artery hemodynamics. Maddrey's discriminant function (MDF) can identify patients with poor prognosis (DF >32). We studied hepatic artery hemodynamic parameters of hepatic artery diameter (HAD), resistive index (RI) and pulsatility index (PI) in severe acute alcoholic hepatitis (SAAH) and for the presence of correlation of paramet...