n-Octyl beta-D-thioglucopyranoside, a new non-ionic detergent, was synthesized. Properties, and applicability to membrane proteins, of this detergent were investigated. The detergent was easily removed by dialysis. The solubilizing power of this detergent for Escherichia coli membrane proteins was similar to that of n-octyl beta-D-glucopyranoside, which has been widely used in membrane biochemi...

Piperine (PIP) is a phytopharmaceutical with reported neuroprotective potential in Alzheimer's disease (AD). Oral PIP delivery suffers from its hydrophobicity and presystemic metabolism. In this article, mono-disperse intranasal chitosan nanoparticles (CS-NPs) were elaborated for brain targeting of PIP. Formula optimization was based on particle size (PS), zeta potential (ZP), polydispersity in...

The movement of cucurbit[7]uril (CB[7]) driven by alpha-cyclodextrin (alpha-CD) is investigated by various experimental techniques including NMR, ESI-MS, UV-vis, and ITC. CB[7] can form stable pseudorotaxanes with N-methyl-N'-octyl-4,4'-bipyridinium (MVO2+) and N,N'-dioctyl-4,4'-bipyridinium (OV2+) dication in aqueous solution. CB[7] shuttles between the octyl and bipyridinium moieties in MVO2+...

BACKGROUND Despite the enormous increase in sunscreen use, allergic contact (AC) and photoallergic (PA) reactions to ultraviolet (UV) filters are considered rare. OBJECTIVES To analyse the data from 2715 patients who underwent photopatch testing at St John's Institute of Dermatology during the period 1983-98. METHODS A retrospective analysis of all positive photopatch test episodes was unde...

Due to public health concerns, the Chinese government and the US Consumer Product Safety Commission (CPSC) both introduced test methods for the analysis of phthalate content in childcare items and toys using GC/MS in 2008. These regulatory methods require determination of the presence of six regulated phthalate esters including dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylh...

Dimethyl-carbonate (DMC) is a green carboxymethylation agent for synthesis of the versatile long-chain alkyl carbonates through base-catalyzed transesterification with aliphatic alcohols. Herein, we demonstrated facile preparation novel heterogeneous base catalyst α-KMgPO4 using commercially cheap metal salts via hydrothermal-calcination procedure. The combination temperature programmed desorpt...

Materials: Glycol chitosan (GCS, Mw = 200 kDa; degree of deacetylation = 90%), potassium persulfate, sodium borohydride, succinic anhydride, melittin from bee venom, sodium dodecyl sulfate, D-(+)-trehalose dehydrate, N-succinimidyl 3-[2-pyridyldithio]-propionate (SPDP), tris(2carboxyethyl)phosphine (TCEP), triethlyl amine (TEA), ethylenediaminetetraacetic acid (EDTA), and dimethyl sulfoxide (DM...

‎Let $G$ be a finite and simple graph with vertex set $V(G)$‎. ‎A nonnegative signed total Roman dominating function (NNSTRDF) on a‎ ‎graph $G$ is a function $f:V(G)rightarrow{-1‎, ‎1‎, ‎2}$ satisfying the conditions‎‎that (i) $sum_{xin N(v)}f(x)ge 0$ for each‎ ‎$vin V(G)$‎, ‎where $N(v)$ is the open neighborhood of $v$‎, ‎and (ii) every vertex $u$ for which‎ ‎$f(u...

The current analysis was carried out to determine the chemical components in leaves of R. minima (L.) DC. GC-MS methanolic extract Minima indicated presence 19 compounds. prevailing compounds were 1Pentadecene (14.31), alpha. Bisabolol (10.39%), 1Heptadecene (9.78%), Cyclohexene,4 (1,5dimethyl1,4hexadienyl (7.06%), 3Hexadecene (Z) (8.10%), Caryophyllene (6.58%), Neophytadiene (5.16%), Humulene ...