The influence of tridentate, nitrogen donor ligands, on the stability of gold(III) complexes under physiological conditions was investigated. The interaction of [Au(terpy)Cl](2+) (terpy = 2,2':6'2'' terpyridine), [Au(bpma)Cl](2+) (bpma = bis(pyridyl-methyl)amine), [Au(dien)Cl](2+) (dien = diethylenetriamine) and [AuCl4](-) with the biologically relevant thiols, L-cysteine (L-Cys) and glutathion...

Transition metals have an important place within medicinal inorganic chemistry. Transition metals exhibit different oxidation states and can interact with a number of negatively charged molecules. This activity of transition metals led to the recent development of drugs which are based on metals and are considered to be potential candidates for pharmacological and therapeutic applications. This...

Copper(II) complexes of amino acids and peptides containing the chelating bis(imidazolyl) residues have been reviewed. The results reveal that bis(imidazolyl) analogues of these biomolecules are very effective ligands for metal binding. The nitrogen donor atoms of the chelating agent are the major metal binding sites under acidic conditions. In the presence of terminal amino group the multident...

Nitrogen donor tetradentate ligands 4,4'-bipyridazine (bpdz) and pyridazino[4,5-d]pyridazine (pp) were prepared by inverse electron demand Diels-Alder cycloaddition reactions of 1,2,4,5-tetrazine. Examination of their behaviour towards silver(I) ions revealed a special potential of the ligands for the design of 3D coordination frameworks involving characteristic polynuclear and polymeric silver...

Selective extraction of minor actinides from lanthanides is a critical step in the reduction of radiotoxicity of spent nuclear fuels. However, the design of suitable ligands for separating chemically similar 4f- and 5f-block trivalent metal ions poses a significant challenge. First-principles calculations should play an important role in the design of new separation agents, but their ability to...

The relative ligand donor strengths of 10 pyrazole-derived ligands has been determined with great accuracy, making use of the interdependence between the donor strength of the co-ligand and the (13)C NMR chemical shift of the (i)Pr(2)-bimy carbene signal in trans-[PdBr(2)((i)Pr(2)-bimy)L] complexes ((i)Pr(2)-bimy = 1,3-diisopropylbenzimidazolin-2-ylidene; L = pyrazole-derived ligand). Even subt...

1. INTRODUCTION Nitrogen-rich compounds are unique very reactive substances which have high heats of formation. Pyridine is one of the most well known aromatic cycles where a CH is replaced by a nitrogen atom, but the pyridine ring is only one member of the azine heterocycles, in which one or more CH group of benzene is replaced by π-accepting and σ-donating nitrogen atoms, proceeding from diaz...

The objectives of this experiment were to investigate the application of new ligands including different atoms & evaluation their nucleophile effects against various metals. Chemistry researchers are really interested in this field. From among various ligands, there are some ligands with different coordinating ligands as well. There are great number of intermediate complexes and major elements ...