A B S T R A C T Nitrofurantoin, a commonly used urinary tract antiseptic, has been associated with idiosyncratic pulmonary and hepatic damage. We have used human lymphocytes in vitro to explore the biochemical basis of susceptibility to nitrofurantoin toxicity. The drug itself did not damage the cells as assessed by trypan blue dye exclusion. In the presence of a mouse hepatic microsomal drug-a...

We report a case of an elderly woman who developed a severe, chronic pulmonary reaction to nitrofurantoin therapy that she had taken continuously for three years to prevent urinary tract infections. The patient was taking no other drug known to cause lung disease but the diagnosis was delayed by failure to recognize the association between nitrofurantoin and adverse drug reactions affecting the...

Nitrofurantoin and other agents are actively transported into human and rodent milk. The purpose of this study was to determine whether nitrofurantoin active transport across mammary epithelia occurs basolaterally or apically, using the CIT3 cell culture model of lactation. The CIT3 model actively transports nitrofurantoin in the basolateral to apical direction. Basolateral to apical permeabili...

The majority of patients affected with nitrofurantoin pulmonary toxicity are elderly women [1]. The proposed mechanism of toxicity is either idiosyncratic oxydant-mediated tissue injury by nitrofurantoin metabolites causing depletion of cellular glutathione (chronic form) or by immunological response induced by nitrofurantoin metabolites acting as heptanes and resulting a hypersensitivity react...

This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida. In the 36th week of gestation, the patient was introduced nitrofurantoin 100 mg a day due to symptoms of dysuria and enterococcus isolated from urine culture. After induced delivery at term because of hypertension, repeated laboratory findings showed increased aspartate aminotransferase (AST) and ala...

Nitrofurantoin and other agents are actively transported into human and rodent milk. The purpose of this study was to determine whether nitrofurantoin active transport across mammary epithelia occurs basolaterally or apically, using the CIT3 cell culture model of lactation. The CIT3 model actively transports nitrofurantoin in the basolateral to apical direction. Basolateral to apical permeabili...

Nitrofurantoin is an antimicrobial agent that is commonly used to treat urinary tract infections. It may also be used prophylactically for patients with recurrent urinary tract infection. Several cases and various clinical manifestations of pulmonary reactions to nitrofurantoin have been described in the literature. Early recognition of such reactions may prevent disability and death. This arti...