In the title compound, C(13)H(9)ClN(2)O(5)S, the N-C bond in the C-SO(2)-NH-C segment has a gauche torsion with respect to the S=O bonds. The conformation between the N-H bond and the ortho-nitro group in the sulfonyl benzene ring is syn, and that between the C=O and the meta-Cl atom in the benzoyl ring is anti. The mol-ecule is twisted at the S-N bond, with a torsion angle of 65.41 (38)°. The ...

A concise, stereoselective synthesis of the trans-hydrindane core of the marine natural product dictyoxetane is reported, starting from a Robinson annelation derived bicyclic enone. A phosphorane-mediated, pinacol-like rearrangement of a cis-diol, via a formal 1,2-hydride shift, is used to establish the requisite trans ring junction. (31)P NMR supports the formation of the intermediate phosphor...

In analogy to 4-b-substituted benzoyl)-N-methylpyridinium cations (1 -X's), the title species (2-X's, -X = -0CH3, -CH3, -H, -Br, -COCH3, -N02) undergo two reversible, well-separated (E1122650 mV) one-electron reductions. The effect of substitution on the reduction potentials of 2-X's is much weaker than the effect of the same substituents on 1-X's: the Hammett p-values are 0.80 and 0.93 for the...

The aim of the present study was to synthesis a series of phthalimides based on our previous works and examine their anxiolytic properties. Using a three steps process, phthalimides were prepared from the corresponding di-methyl phthalate derivatives. Phthalic anhydride was nitrated to produce 3-nitrophthalic acid. Ring closer of either 3-nitrophthalic acid or di-methyl phthalate with urea were...

Herein, two title compounds, N-benzoyl-N′-(4′-cyanophenyl)thiourea (1) and N-(4-nitrobenzoyl)-N′-(4′-cyanophenyl)thiourea (2) were synthesized in a high yield, via different applications of aroyl isocyanate 4-aminobenzonitrile. The structure the prepared compounds was characterized by elemental analysis FT-IR, 1H, 13C-NMR spectroscopic methods. crystal compound 1 determined an X-ray single-crys...

Primary cultures of rat embryonic motor neurons deprived of brain-derived neurotrophic factor (BDNF) induce neuronal nitric oxide synthase (NOS) within 18 hr. Subsequently, >60% of the neurons undergo apoptosis between 18 and 24 hr after plating. Nitro-L-arginine and nitro-L-arginine methyl ester (L-NAME) prevented motor neuron death induced by trophic factor deprivation. Exogenous generation o...

In the title compound, C22H18N2O3S, disorder is found in the benzoyl group (A and B), as well as for four C atoms of the cyclo-hexene ring. Two orientations were modeled in a 0.583 (5):0.417 (5) ratio. The cyclo-hexene ring is in a distorted chair conformation. The dihedral angles between the mean plane of the thio-phene ring and the 4-nitro-benzene and phenyl rings are 30.9 (8) and 64.8 (3) (A...

In the title compound, C(14)H(10)N(4)O(5)S·0.5C(3)H(6)O, the nitro-benzoyl and nitro-phenyl groups have trans and cis configurations, respectively, with respect to the thio-urea S atom. The mol-ecular conformation is stabilized by intra-molecular N-H⋯O and C-H⋯S hydrogen bonds. The acetone solvent mol-ecule possesses a crystallographically imposed twofold axis. In the crystal packing, thio-urea...

Considering the astounding biomedicine properties of pharmaceutically active drug, 4-aminophenazone, also known as 4-aminoantipyrine, work reported in this manuscript details formation novel cocrystals rearranged 4-aminophenazone and 4-nitro-N-(4-nitrobenzoyl) benzamide 1:1 stoichiometry under employed conditions for thiourea synthesis by exploiting use its amino component. However, detailed an...