Generation of cell diversity in the vertebrate central nervous system starts during gastrulation stages in the ectodermal germ layer and involves specialized cell groups, such as the organizer located at the midbrain-hindbrain boundary (MHB). Mutations in the zebrafish no isthmus (noi) gene alter development of the MHB, and affect the pax2.1 gene (formerly pax(zf-b)). Analysis of the structure ...

In this paper, a new method, detrended partial-cross-correlation analysis (DPCCA), is proposed. Based on detrended cross-correlation analysis (DCCA), this method is improved by including partial-correlation technique, which can be applied to quantify the relations of two non-stationary signals (with influences of other signals removed) on different time scales. We illustrate the advantages of t...

Această lucrare examinează literatura de specialitate cu privire la integrarea furnizorilor în realizarea de produse noi şi contribuie cu o cercetare empirică pentru a demonstra că diferenţierea tehnologică, performanţele afacerilor, inovarea şi comunicarea dintre companii şi furnizorii lor sunt pozitiv asociate cu nivelul de integrare al furnizorilor în realizarea de produse noi. În final, est...

In view of the importance of noi se in physiology. information processing and fi nance, studi es on chaos and noi se have been undertaken. Detailed stud ies on the lal lowing osc illatory reactions have been undertaken: (i) thi ophenol + BrO,' + H2S0~, (ii ) fruClose + BrO,' + H2S04 + Ce 4 + , and (iii ) iodate + arsenitc, wh ich can serve as a model system for thi s purposc. Aperiodic oscil la...

Title: Dynamical seasonal prediction of tropical Indo-Pacific SST and Australian rainfall with improved ocean initial conditions. CSIRO and the Bureau of Meteorology advise that the information contained in this publication comprises general statements based on scientific research. The reader is advised and needs to be aware that such information may be incomplete or unable to be used in any sp...

Despite advances over the last two decades in the capacity to predict the evolution of the El Niño–southern oscillation (ENSO) phenomenon and advances in understanding of the relationship between ENSO and climate, there has been little use of climate predictions for water resources management in the tropics. As part of an effort to develop such a prediction scheme, the ENSO influences on stream...

A cohort of 2270 white women, aged 40-69 years at baseline, were followed for an average of 8.5 years in the Lipid Research Clinics Program Follow-up Study. There were 44 deaths due to cardiovascular disease among the 1677 nonusers of estrogens and six cardiovascular disease deaths among the 593 estrogen users. The age-adjusted relative risk (RR) of cardiovascular disease deaths in users compar...

Mutations in two genes affect the formation of the boundary between midbrain and hindbrain (MHB): no isthmus (noi) and acerebellar (ace). noi mutant embryos lack the MHB constriction, the cerebellum and optic tectum, as well as the pronephric duct. Analysis of noi mutant embryos with neuron-specific antibodies shows that the MHB region and the dorsal and ventral midbrain are absent or abnormal,...

During the development of the zebrafish nervous system both noi, a zebrafish pax2 homolog, and ace, a zebrafish fgf8 homolog, are required for development of the midbrain and cerebellum. Here we describe a dominant mutation, aussicht (aus), in which the expression of noi and ace is upregulated. In aus mutant embryos, ace is upregulated at many sites in the embryo, while noi expression is only u...