Until the introduction of metronidazole, the treatment of trichomonal vaginitis presented a considerable therapeutic problem. Local treatment was commonly followed by recurrence of the condition, doubtless partly because vaginal treatment alone failed to eliminate all foci of infection. Moreover, it became apparent that trichomonal infection was also often present in the male (Watt and Jennison...

PURPOSE Hypoxia adversely relates with prognosis in human tumours. Five hypoxia specific predictive marker assays were compared and correlated with definitive radiotherapy. PATIENTS AND METHODS Sixty-seven patients with advanced head and neck carcinomas were studied for pre-treatment plasma osteopontin measured by ELISA, tumour oxygenation status using pO(2) needle electrodes and tumour osteo...

Twelve 4- and 5-nitroimidazole derivatives, including metronidazole and two of its metabolites, tinidazole, dimetridazole, and nimorazole, were tested for antitrichomonad action on Tritrichomonas foetus (KV(1)) and Trichomonas vaginalis (ATCC 30001) for mutagenicity on a nitroreductase-positive (TA 100) and a nitroreductase-deficient (TA 100-FR(1)) strain of Salmonella typhimurium, as well as f...

Awareness increases that the tumor biology influences treatment outcome and prognosis in cancer. Tumor hypoxia is thought to decrease sensitivity to radiotherapy and some forms of chemotherapy. Presence of hypoxia may be assessed by investigating expression of endogenous markers of hypoxia (EMH) using immunohistochemistry (IHC). In this systematic review we investigated the effect of EMH expres...

'The discovery of the growing spread of trichomoniasis is due to improved methods of research. Increased morbidity has accompanied inadequate treatment and is especially due to the confused view of the problem, which is a joint task for gynaecologists, venereologists, and urologists. It may be described as a venereal disease because it is transmitted in the great majority of cases by sexual int...