نتایج جستجو برای: nicotinic acid

تعداد نتایج: 755376  

Journal: :Molecular pharmacology 2001
A Lorenzen C Stannek H Lang V Andrianov I Kalvinsh U Schwabe

Nicotinic acid is a lipid-lowering agent widely used to treat hypertriglyceridemia and to elevate low high density lipoprotein levels. However, the underlying mechanisms are poorly understood. In this study, G protein activation by nicotinic acid and derivatives was assessed as stimulation of guanosine 5'-(gamma-[(35)S]-thio)triphosphate ([(35)S]GTPgammaS) binding, and [(3)H]nicotinic acid was ...

Somayeh Amjadi Taher Alizadeh,

The foregone studies have shown that nicotinic acid cannot produce noticeable reductive signal at carbon-based electrodes without appropriate modification of the electrode. This is an obvious reason that mercury is known as the main electrode material for electro-reduction of nicotinic acid. In this study, it has been shown that it is possible to create a remarkable reduction signal for NA at a...

2006
Lars A. Carlson Rudolf Altschul

Some fifty years ago the Canadian pathologist Rudolf Altschul discovered that nicotinic acid in gram doses lowered plasma cholesterol in man, an effect surprisingly not shared by nicotinamide [1]. Altschul had also shown that nicotinic acid lowered plasma cholesterol and reduced aortic atherosclerosis in the cholesterol-fed rabbit. At that time, 5 years before bile acid sequestrants and 6-8 yea...

2017
D. X. ZHAO

Nicotinic acid and niacinamide are used in a variety of therapeutic application as important components of the co-factors, nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Decreasing the adverse effects will improve the stability and absorption of nicotinic acid. Nicotinic acid aspartic acid dipeptide and tetrapeptide were synthesized via Fmoc solid-phase synth...

Journal: :The Journal of biological chemistry 1960
M V ORTEGA G M BROWN

It has now been firmly established that mammals and Neurospora are able to convert tryptophan to nicotinic acid via a biosynthetic pathway which contains several well characterized intermediate compounds (2). However, evidence has been accumulating which indicates that in bacteria the biosynthesis of nicotinic acid is accomplished by a different pathway. Volcani and Snell (3) demonstrated that ...

Journal: :Clinical chemistry 1978
N Hengen V Seiberth M Hengen

We report a liquid-chromatographic procedure for determining free nicotinic acid and a metabolite, nicotinuric acid, in plasma and urine. Five-tenths milliliter of urine or deproteinized plasma is evaporated and the residue analyzed isocratically by reversed-phase ion-pair chromatography, with measurement of the eluted nicotinic acid and nicotinuric acid at 254 nm. Nicotinic acid, nicotinuric a...

Journal: :Applied and environmental microbiology 1988
C D Mathew T Nagasawa M Kobayashi H Yamada

The nitrilase which occurs abundantly in cells of Rhodococcus rhodochrous J1 catalyzes the direct hydrolysis of 3-cyanopyridine to nicotinic acid without forming nicotinamide. By using resting cells, the reaction conditions for nicotinic acid production were optimized. Under the optimum conditions, 100% of the added 3-cyanopyridine could be converted to nicotinic acid, the highest yield achieve...

Journal: :The Journal of biological chemistry 1959
T A LANGAN N O KAPLAN L SHUSTER

The administration of nicotinamide to the mouse results in an Sto lo-fold increase in the diphosphopyridinc nucleotide content of the liver as previously reported by Kaplan et al. (l-3). Corresponding doses of nicotinic acid are far less effective than nicotinamide in eliciting a net synthesis of DPN (3). This is in contrast to the nicotinic acid specificity which has been observed for DPN synt...

2003
B. CONNOR JOHNSON

The nicotinic acid assay most generally satisfactory is the Lactobacillus arabinosus procedure (1, 2) as regards sensitivity and non-interference from other compounds. However, this organism responds to nicotinamide and nicotinuric acid as well as to nicotinic acid. Gaines and Stahly (3) have proposed the use of Leuconostoc mesenteroides for the assay of several members of the vitamin B complex...

Journal: :Molecular cancer therapeutics 2010
Uffe Høgh Olesen Annemette V Thougaard Peter Buhl Jensen Maxwell Sehested

Inhibitor of nicotinamide phosphoribosyltransferase APO866 is a promising cancer drug currently in phase II clinical trials in oncology. Here, we present a strategy for increasing the therapeutic potential of APO866 through the rescue of normal tissues by coadministration of nicotinic acid (Vitamin B(3)). We examined the toxicity profile of APO866 in B6D2F1 mice and the effect of oral administr...

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