In studies on the regulation of gene expression, there has been considerable interest in the non-histone (NHC) proteins associated with histones and DNA in chromatin [l-5] . Such NHC proteins are reportedly present in large amounts, i.e. 50-l 50% of DNA content by weight [ 1,2] , and display some tissue and species specificity [l-5] , which has implicated them in gene activation and regulation ...

Previously, alkylgold(III) fluorides have been proposed as catalytic intermediates that undergo C-C coupling with reagents such as arylboronic acids in Au(I)/Au(III) cross-coupling reactions. Here is reported the first experimental evidence for this elementary mechanistic step. Complexes of the type (NHC)AuMe (NHC = N-heterocyclic carbene) were oxidized with XeF(2) to yield cis-(NHC)AuMeF(2) pr...

Three types of Au(I) N-heterocyclic carbene (NHC) and imidazole (Im) complexes, namely [Au(NHC)Cl], [Au(NHC)(Im)][NO(3)], and [Au(NHC)(2)][NO(3)], with two-, three-, and four-N-long alkyl chains, respectively, were synthesized and their mesomorphic properties investigated. Only the [Au(NHC)(Im)][NO(3)] series of compounds, adopting an m-shaped conformation in the solid state, showed liquid crys...

Palladium complexes containing 2,7-bis(mesitylimidazolylidenyl)naphthyridine (NHC-NP) have been synthesized and characterized. Reaction of [{Ag(3)(NHC-NP)(2)}(PF(6))(3)] with [Pd(PhCN)(2)Cl(2)] provided an unusual dipalladium complex bridged by two NHC-NP units, forming a 20-membered dinuclear metallacycle [{Pd(2)(NHC-NP)(2)Cl(2)}(PF(6))] (2) in high yield. Treatment of 2 with KI in acetone yie...

This paper describes nhc a compiler for a subset of Haskell. Nhc is the result of the author’s wish to have a Haskell compiler for his Acorn A5000 to play with. Previous the only Haskell system available for A5000 was Mark Jones’ gofer. The disadvantage of gofer is that it is written in C so the play part isn’t as fun as it could be. Nhc is written in Haskell with a small run-time system in C. ...

The reaction of N-heterocyclic carbenes with polyaminoboranes [MeNH-BH2]n or [NH2-BH2]n at 20 °C led to depolymerisation and the formation of labile, monomeric aminoborane-NHC adducts, RNH-BH2-NHC (R = Me or H); a similar NHC adduct of Ph2N=BCl2 was characterized by single crystal X-ray diffraction.

Three new Au(I) complexes of the formula [Au(NHC)(NTf2)] (NHC = N-heterocyclic carbene) bearing bulky and flexible ligands have been synthesised. The ligands studied are IPent, IHept and INon which belong to the 'ITent' ('Tent' for 'tentacular') family of NHC derivatives. The effect of these ligands in gold-promoted transformations has been investigated.

Dedicated to Professor Heinrich Nöth on the occasion of his 85th birthday Gold complex [AuCl(NHC)] (NHC = N,N′-dipropylbenzimidazolin-2-ylidene) 1 undergoes facile substitution reactions at the gold(I) center. Treatment of 1 with anionic phenylacetylide or thiophenolate led to the neutral gold complexes 2 and 3, respectively. The cationic gold complexes [Au(NHC)(pyridine)](BF4) [4]BF4 and [Au2(...

Main-chain organometallic polymers were synthesized from bimetallic iron(ii) complexes containing a ditopic N-heterocyclic carbene (NHC) ligand [(cp)(CO)LFe(NHC approximately NHC)Fe(cp)(CO)L]X(2) (where NHC approximately NHC represents a bridging dicarbene ligand, L = I(-) or CO). Addition of a diimine ligand such as pyrazine or 4,4'-bipyridine, interconnected these bimetallic complexes and gav...

A series of novel imidazolium salts bearing hydrophilic tetraethylene glycol (TEG) and/or hydrophobic long-chain alkyl (n-C12) functionalities, which are precursors for desired N-heterocyclic carbene (NHC) ligands, were synthesized and characterized. Rh(I)-NHC complexes were prepared in good yields by the silver carbene transfer method with NHC-Ag species derived from the imidazolium salts. The...