Cisplatin (cis-diamminedichloroplatinum II, CDDP) acts as a therapeutic agent by initiating cellular apoptosis. However, side-effects and drug resistance limit the clinical use of cisplatin. Numerous studies have focused on the drug-target interactions, cellular pharmacology and pharmacokinetics of cisplatin. Newly developed treatment strategies are needed in order to be used in combination wit...

Microalgae shows a high potential to produce biofuel and forward osmosis (FO) has been proposed as promising dewatering process for algal biomass separation from water. However, the effect of reverse salt flux (RSF) on during using FO not completely explored. This study was investigate different types their concentrations in terms conductivity, settling velocity, lipid contents FS simulated FO-...

In a resorption heat pump, the adsorption and desorption reaction of ammonium chloride (NH4Cl) with ammonia (NH3) is interest as Low Temperature Salt (LTS). Reviewing previously published NH4Cl-NH3 equilibrium lines, appears to offer useable working temperatures (50–70 °C) in 10–15 bar pressure range during reaction, provides beneficial conditions for when compared alternative LTS candidates at...

The influence of water deprivation at the onset of lay on subsequent eggshell quality, fecal moisture content and blood physiology was investigated in ISA Brown pullets. Kidney and bone appearances were also determined at the end of the study. The pullets were randomly divided into 3 groups; control, dehydrated, and dehydrated+NH4Cl groups. The birds in the control group were provided a layer d...

Studies were made on whether ammonia, which is an obligatory intermediate of amino acid metabolism, depresses the food intake of rats fed a low-casein (basal) diet containing imbalanced amino acid mixtures (imbalanced diets). Bilateral lesions in the prepyriform cortex caused normalization of food intake of rats fed amino acid-imbalanced diets, confirming the work of Leung and Rogers (Am. J. Ph...

The interactions between HCl and NH3 molecules adsorbed on amorphous solid water (ASW) have been investigated by temperature-programmed time-of-flight secondary ion mass spectrometry (TP-TOF-SIMS). The NH4 þ ion is sputtered predominantly from codeposited HCl and NH3 molecules on ASW due to collision-induced proton transfer reactions. The NH4 þ yield is enhanced above 60 K as a consequence of t...

Alkali-enriched diets are recommended for humans to diminish the net acid load of their usual diet. In contrast, herbivores have to deal with a high dietary alkali impact on acid-base balance. Here we explore the role of nutritional alkali in experimentally induced chronic metabolic acidosis. Data were collected from healthy male adult rabbits kept in metabolism cages to obtain 24-h urine and a...

Hepatic failure (HF) is caused by several factors, which induce liver cell damage and dysfunction. However, the specific mechanism of HF remains to be fully elucidated. The present study aimed to investigate the underlying cause of hepatocyte injury and liver dysfunction. Liver cells were isolated from healthy female Sprague‑Dawley rats, aged between 6 and 8 weeks, weighing ~230 g. The liver ce...