The renin-angiotensin system regulates cardiovascular physiology via angiotensin II engaging the angiotensin type 1 or type 2 receptors. Classic actions are type 1 receptor mediated, whereas the type 2 receptor may counteract type 1 receptor activity. Angiotensin-converting enzyme 2 metabolizes angiotensin II to angiotensin-(1-7) and angiotensin I to angiotensin-(1-9). Angiotensin-(1-7) antagon...

in the present study, interactions between lead exposure with nitric oxide precursor (l-arginine) or nitric oxide synthase (nos) inhibitor (l-name) on naloxone-induced jumping and diarrhea in morphine-dependent mice were examined. chronic lead acetate (0.05%) exposure altered naloxone-induced jumping and diarrhea in mice. jumping was decreased after 7 days and was unchanged 14 and 28 days after...

Objective(s): We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats. Materials and Methods: I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was performed using four cycles of 2 min occlusions of the left femoral artery an...

objective(s) single injection of naloxone, a selective antagonist of morphine, prior to the drug conditioning testing was used to investigate on morphine dependence. materials and methods conditioning to morphine (2.5-10 mg/kg, s.c.) was established in adult male wistar rats (weighing 200-250 g) using an unbiased procedure. nitric oxide agents were microinjected into the central amygdala prior ...

It has been shown that nitric oxide (NO) increases aggression in male mice, whereas it decreases aggression in lactating female mice and prairie voles. It is also known that aggression can be exhibited at different levels in rodent species, strain or subtypes. The aims of this study were to investigate the proportion of aggressiveness in Wistar rats, the effect of intraperitoneally administered...

  The involvement of nitric oxide (NO) in the reinforcing properties of opioids was studied by examining the effect of a NO precursor (L-arginine) and NO synthase inhibitor (L-nitro-amino-methyl-ester, L-NAME) on the conditioned place preference (CPP) induced by morphine. The experiment was performed on male albino Swiss- White mice (25 ± 5 g). L-arginine in doses of 100, 200 and 500 mg/kg (i.p...

The dibasic amino acid, L-arginine, is a substrate for both nitric oxide synthase (NOS) and arginase and therefore, plays an important role in cell signaling and cell growth. We examined the effects of various NOS inhibitors on L-arginine transport into rat renal brush border membrane (BBM) vesicles. L-Arginine uptake was stimulated in the presence of an inwardly directed Na+ gradient and an im...

background: role of nitric oxide (no) in morphine-induced conditioned place preference (cpp) has already been proposed in the rat medial septum (ms), but no molecular evidence has been provided to clear this fact. methods: effects of intraseptal injections of l-arginine and/or ng-nitro-l-arginine methyl ester (l-name) on morphine place conditioning in wistar rats were examined. morphine (2.5-7....

effects of intra-central amygdala administration of l-arginine, a nitric oxide precursor, and ng-nitro-l-arginine methyl-ester (l name), a nitric oxide synthase inhibitor, on the morphine-induced sensitization and also on the expression of morphine-induced place conditioning in rats were studied. subcutaneous (s.c.) administration of morphine (2.5, 5 and 7.5 mg/kg) induced place conditioning. r...