The purpose of the current study was to evaluate the anti-inflammatory activity of tetramethlpyrazine on oxazolone-induced colitis mice. Spleen mononuclear cells (SMC), lamina propria mononuclear cells (LPMC) and peripheral blood mononuclear cells (PBMC) were isolated from oxazolone-induced colitis and normal mice. The colitis cells treated by oxazolone were randomly divided into model, low dos...

The purpose of the current study was to evaluate the anti-inflammatory activity of tetramethlpyrazine on oxazolone-induced colitis mice. Spleen mononuclear cells (SMC), lamina propria mononuclear cells (LPMC) and peripheral blood mononuclear cells (PBMC) were isolated from oxazolone-induced colitis and normal mice. The colitis cells treated by oxazolone were randomly divided into model, low dos...

3,4-Dihydroxybenzalacetone (DBL) is a polyphenol derived from the medicinal plant Chaga [Inonotus obliquus (persoon) Pilat]. Although Chaga is used in Russia folk medicine to treat tumors, very little is known about its mechanism of action. Because most genes involved in inflammation, antiapoptosis, and cell proliferation are regulated by the transcription factor nuclear factor-KB (NF-KB), we p...

Gukovsky, Ilya, Anna S. Gukovskaya, Thane A. Blinman, Vjekoslav Zaninovic, and Stephen J. Pandol. Early NF-kB activation is associated with hormone-induced pancreatitis. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G1402–G1414, 1998.—Inflammation and cell death are critical to pathogenesis of acute pancreatitis. Here we show that transcription factor nuclear factor-kB (NF-kB), which r...

Objective Inflammatory changes in the amniotic membranes during prenatal period have a critical important rupture of and onset labor. The inflammatory caused by normal vaginal labors cesarean sections (C/S) are different than each other. Nuclear factor-kappa B (Nf- kB) is basic cellular marker inflammation change biological fluids tissues. We planned this study to compare fluid NF-kB (AF-NF-kB)...

Nuclear factor-kappaB (NF-kB) is a key inflammatory transcription factor expressed frequently in tumors. Numerous studies have investigated the correlation between NF-kB expression and prognosis in solid tumors, but the conclusions are still in contradiction. Here, we conduct a meta-analysis to explore the overall association of NF-kB overexpression and survival in human solid tumors. Pubmed an...

The IkB kinases (IKKs) lie downstream of the NF-kBinducing kinase (NIK) and activate NF-kB by phosphorylation of IkBa. This leads to IkBa degradation and release of NF-kB. In U937 monocytic cells, interleukin (IL)-1b (1 ng/ml) and tumor necrosis factor (TNF)-a; 10 ng/ml) induced kB-dependent transcription equally. However, IKK activity was strongly induced by TNF-a but not by IL-1b. This was co...

Some studies have demonstrated the involvement of nuclear factor-kappa B (NF-kB) in the pathogenesis of glomerulonephritis. The aim of our study was twofold: (1) to analyze the prognostic value of NF-kB expression in primary IgA nephropathy (IgAN) and (2) to compare the results of NF-kB expression by immunohistochemistry (IHC) and southwestern histochemistry (SWH). We analyzed 62 patients diagn...

The notion that nuclear factor-KB (NF-KB) is a tumorpromoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-KB in carcinogenesis and tumorigenesis. Although the tumor suppressor–like effect of NF-KB remains to be rigorously established by further studies using cellular and animal models, these latest findings warra...

The transcription factor nuclear factor-kB (NF-kB) is central to the innate and acquired immune response to microbial pathogens, coordinating cellular responses to the presence of infection. Here we demonstrate a direct role for NF-kB activation in controlling intracellular infection in nonimmune cells. Trypanosoma cruzi is an intracellular parasite of mammalian cells with a marked preference f...