NF B is a critical transcription factor involved in modulating cellular responses to environmental injuries. Tyrosine 42 phosphorylation of I B has been shown to mediate NF B activation following hypoxia/ reoxygenation (H/R) or pervanadate treatment. This pathway differs from the canonical proinflammatory pathways, which mediate NF B activation through serine phosphorylation of I B by the IKK c...

Tumor necrosis factor receptor 1 (TNFR1) activates NF-?B–dependent pro-inflammatory gene expression, but also induces cell death by triggering apoptosis and necroptosis. Inhibition of inhibitor NF-?B kinase (IKK)/NF-?B signaling in keratinocytes paradoxically unleashed spontaneous TNFR1-mediated skin inflammation mice, the underlying mechanisms remain poorly understood. Here, we show that TNFR1...

Increased X-linked inhibitor of apoptosis (XIAP) expression and suppressed follicular apoptosis are important determinants in the regulation of follicular development by FSH. The objective of the present study was to examine the role and regulation of nuclear factorB (NF B) in the gonadotropic control of granulosa cell XIAP expression and follicular growth in vitro. FSH (100 ng/ml) increased ra...

T cell activation causes the translocation of NF-κB dimers from the cytoplasm into the nucleus where NF-κB regulates inflammatory and immune response genes. Cbl-b is a negative regulator of T cell activation. However, the correlation between NF-κB activity and Cbl-b expression remains unclear. We showed that IκBαΔN-Tg T cells exhibited less NF-κB activity but higher levels of Cbl-b when compare...

Necrotizing fasciitis (NF) is a severe soft tissue infection, characterized by rapid and fulminant progression. Thus, early suspicion, prompt medical aggressive surgical management are important for the clinical outcomes of NF. Despite rarity NF in infants group B streptococcus as its cause, 2-month-old preterm girl presented with involving suprapubic, inguinal, lower lateral abdominal regions ...