Neurotoxicity of beta-amyloid peptide (A beta) in Alzheimer's disease (AD) is usually thought to arise from the nonspecific effects of high concentrations of A beta on vulnerable neurons, resulting in membrane destabilization and increasing intracellular calcium concentration. This review advances the hypothesis that at early stages of AD, when A beta is present in lower amounts, its ability to...

Abstract. Starting from an exact counting of small and positive cosmological constant states in the Bousso-Polchinski Landscape we recover a well-known approximate formula and a systematic method of improvement by means of the Poisson summation formula. This is a contribution to the special Volume published by the University of Zaragoza in honor of Julio Abad Antoñanzas. En memoria de nuestro a...

Perhaps it is because I am not a professional medicinal chemist, or possibly it is because I am a person that prefers the visual presentation of data as opposed to a long list of numbers in parallel vertical columns; either way, the fact is that the conventional structure–activity relation tables (SAR-tables), which have been and still are the essential item in most medicinal chemistry papers, ...

Can Yao,1 Francisco J. Rodriguez,1 Jorge Bravo-Abad,2 and Jordi Martorell1,3 1ICFO-Institut de Ciencies Fotoniques, Mediterranean Technology Park, 08860 Castelldefels, Barcelona, Spain 2Departamento de Fı́sica Teórica de la Materia Condensada, Universidad Autónoma de Madrid, E-28049 Madrid, Spain 3Departament de Fı́sica i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Terrassa, Spain (...

Biology of a nocturnal bee, Megalopta atra (Hymenoptera: Halictidae; Augochlorini), from the Panamanian highlands Simon M. Tierney a; Therany Gonzales-Ojeda b; William T. Wcislo a a Smithsonian Tropical Research Institute, Ancón, Panama b Facultad de Ciencias Forestales y Medio Ambiente, Universidad Nacional de San Antonio Abad del Cusco Sede Puerto Maldonado Jr. San Martín 451, Madre de Dios, ...

This paper presents the results of research carried out to improve emergency response activities in earthquake-prone areas of Iran. The research concentrated on emergency response operations, emergency medical care, emergency transportation, and evacuation-the most important issues after an earthquake with regard to saving the lives of victims. For each topic, some guidelines and criteria are p...

By Christopher Abad, Research Scientist ABSTRACT Phishing has been defined as the fraudulent acquisition of personal information by tricking an individual into believing the attacker is a trustworthy entity1. Phishing attacks are becoming more sophisticated and are on the rise. In order to develop effective strategies and solutions to combat the phishing problem, one needs to understand the inf...