Utilizing a classic stroke model in rodents, middle cerebral artery occlusion (MCAo), we describe a novel neuroregenerative approach using the repeated intranasal administration of cocaine- and amphetamine-regulated transcript (CART) peptide starting from day 3 poststroke for enhancing the functional recovery of injured brain. Adult rats were separated into two groups with similar infarction si...

Glycosaminoglycans (GAGs) play critical roles in diverse processes ranging from viral infection to neuroregeneration. Their regiospecific sulfation patterns, which are generated by sulfotransferases, are key structural determinants that underlie their biological activity. Small-molecule modulators of these sulfotransferases could serve as powerful tools for understanding the physiological funct...

1College of Medicine, University of Central Florida, Orlando, FL 32827, USA 2Eve Topf and US National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research and Teaching, Technion-Rappaport Faculty of Medicine, Haifa, Israel 3Department of Biology, Yonsei University, Seoul, Republic of Korea 4Karolinska Institutet, Alzheimer Neurobiology Center, Karolinska Universit...

Kamen G. Usunoff1,2, Oliver Schmitt2, Nikolai E. Lazarov1, Dimitar E. Itzev3, Arndt Rolfs4, and Andreas Wree2 1Department of Anatomy and Histology, Medical University, Sofia, Bulgaria, 2Institute of Anatomy, University of Rostock, Rostock, Germany, 3Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria, and 4Albrecht-Kossel-Institute of Neuroregeneration, Centеr for Mental H...

Jianhua Shi, Wei Qian, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Xiaosong Gu, Fei Ding, Cheng-Xin Gong, and Fei Liu From Jiangsu Key Laboratory of Neuroregeneration and Department of Biochemistry, Medical School, Nantong University, Nantong, Jiangsu 226001, P. R. China; Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, N...