Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in an animal model ...

Excitotoxicity has been implicated in the etiology of ischemic stroke and chronic neurodegenerative disorders. Hence, the development of novel neuroprotectant molecules that ameliorate excitotoxic brain damage is vigorously pursued. We used a neuroprotection-based cellular assay to screen a synthetic combinatorial library of N-alkylglycine trimers. Two compounds (6-1-2 and 6-1-10) that efficien...

To date, no drug has been proven to be neuroprotective or disease-modifying for Parkinson's disease (PD) in clinical trials. Here, we aimed to assess preclinical evidence of Ginsenosides-Rg1 (G-Rg1), a potential neuroprotectant, for experimental PD and its possible mechanisms. Eligible studies were identified by searching six electronic databases from their inception to August 2016. Twenty-five...

971 May 2015 F OR chemists and physicists, xenon is a noble gas with 54 protons and low reactivity (or “inert”) due to an outer shell that is replete with electrons. For anesthesiologists, xenon is a drug with remarkable properties as a fast-acting anesthetic, analgesic, cardioprotectant, and neuroprotectant.1,2 But how does it work? In this issue of AnesthesIOlOgy, Mattusch et al.3 report an i...

The processes and mechanisms underlying brain injuries due to ischemia and anoxia have yet to be determined. Additionally, few clinical treatements are currently available. Activins have a protective role in the restoration, differentiation, and survival of injured cells, including Activin A (ActA), which acts as a neuroprotectant. However, its exact mechanism of action remains to be determined...

On exploratory class missions to other planets astronauts will be exposed to types and doses of radiation that are not experienced in low earth orbit. While it is likely that the crew will consist of both male and female astronauts, there has been little research on the effects of exposure to space radiation on central nervous system function and cognitive performance in female subjects. Becaus...

We reported a case report of 50-year-old woman with stroke hemorrhage due to subarachnoid hypertensive urgency, left ventricular hypertrophy, and dyslipidemia. Subarachnoid indicates the presence blood in space between pia mater arachnoid which usually results from ruptured cerebral aneurysm or arteriovenous malformation. The patient presents decreased consciousness preceded by severe headache ...

Wake neurons in the basal forebrain and brainstem provide critical inputs to optimize alertness and attention. These neurons, however, evidence heightened vulnerability to a diverse array of metabolic challenges, including aging. SIRT1 is an nicotinamide adenine dinucleotide responsive deacetylase serving diverse adaptive responses to metabolic challenges, yet this metabolic rheostat may be dow...