objective(s) it is well known that prenatal stresses (ps) induce a variety of neurobiological and behavioral alterations, some of them involving the hippocampal formation. this study aimed to determine whether restraint stress influences the neuronal volume and number of granule cells in the hippocampus of adult rat offspring. materials and methods ten wistar pregnant rats were randomly divided...

background: sandhoff disease is an autosomal recessive disorder caused by β-hexosaminidase deficiency and accumulation of gm2 ganglioside resulting in progressive motor neuron manifestations and death from respiratory failure and infections in infantiles. pathogenic mutations in hexb gene were observed which leads to enzyme activity reduction and interruption of normal metabolic cycle of gm2 ga...

background and objectives: studies have documented the morhplogical, neurochemical and functional difference between the dorsal and ventral zones of hippocampus. the aim of this study was to assess the effects of chronic diabetes mellitus type1 on ventral and dorsal zones of hippocampus. methods: experimental diabetes was induced by stereptozotocin at a dose of 60 mg/kg. at the end of 8 weeks ...

background and objective: sensory neurons have critical role in improvement of functional outcome of any neuroprotective strategy. the herbal medicine nepeta menthoides has been reported to have anti-apoptotic effect on axotomized spinal motoneurons. in the present study, the putative neuroprotective effect of nepeta menthoides on the axotomized dorsal root ganglion sensory neurons in neonate r...

In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...

introduction cholinergic system is one of the important systems of mammalian cns. cholinergic neurons distributed in brain and spinal cord and contributed to principal functions like: consciousness, learning and memory, and motor control. in this study we investigated the differentiation potentiality of mouse embryonic stem cells toward cholinergic neurons. the aim of this study was to evaluate...

objective(s) motor deficit and neuron degeneration is seen after nerve transection. the aim of this study is to determine whether a poled polyvinelidene fluoride (pvdf) tube with other supportive strategies can protect the neuronal morphology and motor function after sciatic nerve transaction in rats. materials and methods after transection of the left sciatic nerve in 60 male wistar rats (200-...

this paper addresses synchronizing two coupled chaotic fitzhugh–nagumo (fhn) neurons with weakly gap junction under external electrical stimulation (ees). to transmit information among coupled neurons, by generalization of the integer-order fhn equations of the coupled system into the fractional-order in frequency domain using crone approach, the behavior of each coupled neuron relies on its pa...