OBJECTIVE To determine the seroprevalence of neuromyelitis optica antibody (NMO)-IgG in Brazilian patients with clinical diagnosis of relapsing neuromyelitis optica, also known as Devic's disease. METHOD We determined NMO-IgG titers in 28 patients (25 of them females) that fulfilled the 1999 NMO diagnostic criteria proposed by Wingerchuk et al. RESULTS NMO-IgG was detected in 18 NMO patient...

Neuromyelitis optica (NMO) is an inflammatory disorder of the CNS with prominent involvement of the optic nerve and the spinal cord. An autoantibody against aquaporin-4 (AQP4), a water channel abundant on astrocytic foot processes, is the biomarker of the disease. The term neuromyelitis optica spectrum disorders (NMOSD) includes AQP4-IgG-positive syndromes that may only partially fulfill contem...

UNLABELLED Tonic spasms have been most commonly associated with multiple sclerosis. To date, few reports of series of patients with neuromyelitis optica and tonic spasms have been published. METHODS We analyzed the characteristics and frequency of tonic spasms in 19 subjects with neuromyelitis optica. Data was collected using a semi-structured questionnaire for tonic spasms, by both retrospec...

INTRODUCTION Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system. To date, optimal therapeutic approaches for neuromyelitis optica have yet to be defined. Natalizumab is highly effective in relapsing-remitting multiple sclerosis and might be considered as an option. CASE PRESENTATION Here, we describe a 67-year-old Caucasian man with definite neuromyeli...

background: neuromyelitis optica (nmo) is an uncommon neuro- inflammatory syndrome that has shown to be distinct from multiple sclerosis (ms) and associated with the autoantibody marker nmo-immunoglobulin g (igg). there are still only a few studies regarding the epidemiology of nmo in iran. in the present study, we tried to describe the epidemiology of nmo in khuzestan as one of the densely pop...

Abstract Background Neuromyelitis optica is a rare immune-mediated demyelinating central nervous system disorder affecting the spinal cord and optic nerves. There no permanent cure for this disease, its management requires multidisciplinary approach. Objective The objective of case report to see effectiveness physical therapy in neuromyelitis Optica. Methods A 13-year-old female with symptoms l...

Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic re...