BACKGROUND Neurological soft signs are subtle but observable impairments in motor and sensory functions that are not localized to a specific area of the brain. Neurological soft signs are common in schizophrenia. It has been established that soft signs meet two of five criteria for an endophenotype, namely: association with the illness, and state independence. This review investigated whether s...

BACKGROUND Neurological soft signs preceding adult-onset schizophrenia suggest a neurodevelopmental origin and could reflect physical illness in childhood. AIMS To investigate possible associations of adult-onset psychosis with neurological soft signs and common infectious illnesses in childhood. METHOD Using data from the UK National Child Development Study, a longitudinal general populati...

Neurological soft signs have been observed in patients with schizophrenia and their relatives. However, it has not been considered whether the increased rates of neurological soft signs are related to measures of psychosis proneness in the general population. We tested this hypothesis in a group of normal volunteers (n = 28) who scored highly for positive schizotypy when assessed online and a c...

Objective: The study investigated the relationship between neurological soft signs (NSS) and obstetric complications (OCs) in patients with schizophrenia. Methods: Sixty-three male patients with schizophrenia were divided into two subgroups, based on the OCs presence or absence, which were compared in relation to NSS prevalence. After that, a Person’s correlation test was performed to explore t...

Following empirical studies on schizophrenic and bipolar vulnerabilities, research on endophenotypes knows a recent major development. Two main definitions of early and stable vulnerability markers may be distinguished. First, a strict definition of endophenotype relies on a quantifiable and mainly paraclinical measure (e.g., biological data, electrophysiology or functional imaging). Second, a ...

"PANESS" battery was administered to a total sample of 120 students of five age specific groups of children from two schools catering to the needs of different socio-economic classes. Most commonly observed item was overflow/higher movements (5, N = 24) followed by motor inco-ordination and dysdiadochokinesia, maximally present in the age group of 7 to 8 (6, N = 24). Further results suggest dif...